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The Development of Nonalcoholic Fatty Liver Disease and Metabolic Syndromes in Diet-Induced Rodent Models.
Aljahdali, Bayan Abdulhafid; Bajaber, Adnan Salem; Al-Nouri, Doha M; Al-Khalifah, Abdulrahman Saleh; Arzoo, Shaista; Alasmari, Abeer Abdullah.
Afiliación
  • Aljahdali BA; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
  • Bajaber AS; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
  • Al-Nouri DM; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
  • Al-Khalifah AS; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
  • Arzoo S; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
  • Alasmari AA; Department of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 1495, Saudi Arabia.
Life (Basel) ; 13(6)2023 Jun 07.
Article en En | MEDLINE | ID: mdl-37374119
Dietary macronutrients are essential for metabolic regulation and insulin function. The present study examined the effects of different high-fat diets (HFDs) and high-carbohydrate diets (HCDs) on the development of non-alcoholic fatty liver disease and metabolic syndrome indices in healthy adult male Wistar albino rats. Forty-two rats were distributed into six groups (n = 7), which were fed the following for 22 weeks: (1) a control diet; (2) a high-carbohydrate, low-fat diet (HCD-LFD); (3) high-saturated-fat, low-carbohydrate diet (HSF-LCD); (4) a high-monounsaturated-fat diet (HMUSF); (5) a high medium-chain fat diet (HMCF); and a (6) a high-carbohydrate, high-fiber diet (HCHF). In comparison to the control, the body weight increased in all the groups. The HSF-LCD group showed the highest levels of cholesterol, triglyceride, low-density lipoprotein, hepatic enzyme, insulin resistance, and Homeostatic Model Assessment for Insulin Resistance. A liver histology analysis of the HSF-LCD group showed macrovesicular hepatic steatosis associated with large hepatic vacuolation. Additionally, it showed marked periportal fibrosis, especially around the blood vessels and blood capillaries. The lowest levels of fasting glycemia, insulin, and HOMA-IR were observed in the HCHF group. In conclusion, these findings show that dietary saturated fat and cholesterol are principal components in the development and progression of non-alcoholic fatty liver disease in rats, while fiber showed the greatest improvement in glycemic control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Life (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Life (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza