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C-Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects.
Khomutov, Maxim A; Salikhov, Arthur I; Mitkevich, Vladimir A; Tunitskaya, Vera L; Smirnova, Olga A; Korolev, Sergey P; Chizhov, Alexander O; Gottikh, Marina B; Kochetkov, Sergey N; Khomutov, Alex R.
Afiliación
  • Khomutov MA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Salikhov AI; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Mitkevich VA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Tunitskaya VL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Smirnova OA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Korolev SP; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.
  • Chizhov AO; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii Prosp. 47, Moscow 119991, Russia.
  • Gottikh MB; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.
  • Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
  • Khomutov AR; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia.
Biomolecules ; 13(6)2023 05 31.
Article en En | MEDLINE | ID: mdl-37371496
The biogenic polyamines, spermidine (Spd) and spermine (Spm), are present at millimolar concentrations in all eukaryotic cells, where they participate in the regulation of vitally important cellular functions. Polyamine analogs and derivatives are a traditional and important instrument for the investigation of the cellular functions of polyamines, enzymes of their metabolism, and the regulation of the biosynthesis of antizyme-a key downregulator of polyamine homeostasis. Here, we describe convenient gram-scale syntheses of a set of C-methylated analogs of Spd. The biochemical properties of these compounds and the possibility for the regulation of their activity by moving a methyl group along the polyamine backbone and by changing the stereochemistry of the chiral center(s) are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliaminas Biogénicas / Espermidina Idioma: En Revista: Biomolecules Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliaminas Biogénicas / Espermidina Idioma: En Revista: Biomolecules Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza