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CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/ß-Catenin Pathway.
He, Mingliang; Lv, Xiaoyang; Cao, Xiukai; Yuan, Zehu; Quan, Kai; Getachew, Tesfaye; Mwacharo, Joram M; Haile, Aynalem; Li, Yutao; Wang, Shanhe; Sun, Wei.
Afiliación
  • He M; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Lv X; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
  • Cao X; International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou University, Yangzhou 225009, China.
  • Yuan Z; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
  • Quan K; International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou University, Yangzhou 225009, China.
  • Getachew T; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
  • Mwacharo JM; International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou University, Yangzhou 225009, China.
  • Haile A; College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
  • Li Y; International Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
  • Wang S; International Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
  • Sun W; International Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Animals (Basel) ; 13(12)2023 Jun 19.
Article en En | MEDLINE | ID: mdl-37370543
In our previous study of Hu sheep hair follicles, we found that CRABP2 was highly expressed in DPCs, which suggested that CRABP2 may influence the number of DPCs. In the present study, we aimed to understand the effect of CRABP2 in Hu sheep dermal papilla cells (DPCs). First, we explored the influence of CRABP2 on the ability of Hu sheep DPCs' proliferation. Based on the results obtained from some experiments, such as CCK-8, EDU, qPCR, and Western blot experiment, we found that the overexpression of CRABP2 facilitated the proliferation of DPCs compared to the negative control group. Then, we also detected the effect of CRABP2 on the Wnt/ß-catenin pathway based on the important function of the Wnt/ß-catenin pathway in hair follicles. The results showed that CRABP2 could activate the Wnt/ß-catenin pathway in DPCs, and it rescues the proliferation of DPCs when the Wnt/ß-catenin pathway was inhibited. In summary, our findings indicate that CRABP2 is a vital functional gene in the proliferation of Hu sheep DPCs. Our study will be of great use for revealing the roles of CRABP2 in the hair follicles of Hu sheep.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animals (Basel) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animals (Basel) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza