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Deep learning approach for differentiating indeterminate adrenal masses using CT imaging.
Singh, Yashbir; Kelm, Zachary S; Faghani, Shahriar; Erickson, Dana; Yalon, Tal; Bancos, Irina; Erickson, Bradley J.
Afiliación
  • Singh Y; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Kelm ZS; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Faghani S; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Erickson D; Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
  • Yalon T; Department of General Surgery, Mayo Clinic, La Crosse, WI, USA.
  • Bancos I; Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
  • Erickson BJ; Department of Radiology, Mayo Clinic, Rochester, MN, USA. bje@mayo.edu.
Abdom Radiol (NY) ; 48(10): 3189-3194, 2023 10.
Article en En | MEDLINE | ID: mdl-37369921
PURPOSE: Distinguishing stage 1-2 adrenocortical carcinoma (ACC) and large, lipid poor adrenal adenoma (LPAA) via imaging is challenging due to overlapping imaging characteristics. This study investigated the ability of deep learning to distinguish ACC and LPAA on single time-point CT images. METHODS: Retrospective cohort study from 1994 to 2022. Imaging studies of patients with adrenal masses who had available adequate CT studies and histology as the reference standard by method of adrenal biopsy and/or adrenalectomy were included as well as four patients with LPAA determined by stability or regression on follow-up imaging. Forty-eight (48) subjects with pathology-proven, stage 1-2 ACC and 43 subjects with adrenal adenoma >3 cm in size demonstrating a mean non-contrast CT attenuation > 20 Hounsfield Units centrally were included. We used annotated single time-point contrast-enhanced CT images of these adrenal masses as input to a 3D Densenet121 model for classifying as ACC or LPAA with five-fold cross-validation. For each fold, two checkpoints were reported, highest accuracy with highest sensitivity (accuracy focused) and highest sensitivity with the highest accuracy (sensitivity focused). RESULTS: We trained a deep learning model (3D Densenet121) to predict ACC versus LPAA. The sensitivity-focused model achieved mean accuracy: 87.2% and mean sensitivity: 100%. The accuracy-focused model achieved mean accuracy: 91% and mean sensitivity: 96%. CONCLUSION: Deep learning demonstrates promising results distinguishing between ACC and large LPAA using single time-point CT images. Before being widely adopted in clinical practice, multicentric and external validation are needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenoma / Neoplasias de la Corteza Suprarrenal / Neoplasias de las Glándulas Suprarrenales / Carcinoma Corticosuprarrenal / Adenoma Corticosuprarrenal / Aprendizaje Profundo Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Abdom Radiol (NY) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenoma / Neoplasias de la Corteza Suprarrenal / Neoplasias de las Glándulas Suprarrenales / Carcinoma Corticosuprarrenal / Adenoma Corticosuprarrenal / Aprendizaje Profundo Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Abdom Radiol (NY) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos