P-wave peak time and P-wave dispersion in surface electrocardiography as initial predictors of new-onset atrial fibrillation in early-onset hypertension.

Jagannatha, Gusti Ngurah Prana; Antara, I Made Putra Swi; Kosasih, Anastasya Maria; Kamardi, Stanly; Pradnyana, I Wayan Agus Surya

Jagannatha, Gusti Ngurah Prana; Antara, I Made Putra Swi; Kosasih, Anastasya Maria; Kamardi, Stanly; Pradnyana, I Wayan Agus Surya.

Afiliación

Jagannatha GNP; Faculty of Medicine, Udayana University/Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia. ngurahprana99@gmail.com.
Antara IMPS; Division of Electrophysiology and Cardiac Pacing, Department of Cardiology and Vascular Medicine, Udayana University/Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Kosasih AM; Faculty of Medicine, Udayana University/Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Kamardi S; Faculty of Medicine, Udayana University/Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Pradnyana IWAS; Faculty of Medicine, Udayana University/Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.

Hypertens Res ; 47(1): 137-148, 2024 Jan.

Article en En | MEDLINE | ID: mdl-37369850

RESUMEN

Atrial fibrillation (AF) is common in hypertension, and electrophysiological remodelling may contribute to the early stage of the disease. This study aimed to develop electrocardiography (ECG) prediction models on new-onset AF (NAF) in early-onset hypertension (e-HTN). This matched case-control study included primary hypertension patients with onset <5 years defined as e-HTN and without documented AF. Developed NAF was the risk group and non-developed NAF was control group with 1:2 ratio. Group was matched according to age, gender, follow-up time, and duration of hypertension. Parameters of ECG and echocardiography between the groups at the baseline and end of follow-up will be compared. A total of 348 e-HTN with 116 developed NAF during follow-up (60.2 ± 14.5 months) were included. At baseline ECG, duration of QRS (100.84 ms ± 15.69 ms vs 94.80 ms ± 15.68 ms), Pmax (106.75 ms ± 7.93 ms vs 101.77 ms ± 6.78 ms), Pmin (70.24 ms ± 5.59 ms vs 68.17 ms ± 5.61 ms), P-wave dispersion (PD) (36.50 ms ± 5.25 ms vs 33.60 ms ± 5.46 ms), P-wave Peak Time (PWPT) II (62.01 ms ± 3.92 ms vs 54.29 ms ± 6.73 ms), and PWPT V1 (55.31 ms ± 2.89 ms vs 51.24 ms ± 4.05 ms) were significantly higher in developed NAF (all P-value < 0.05). LVMI was also significantly higher in bivariate analysis, but only Pmax, Pmin, PD, PWPT, non-RAAS inhibitor, and uncontrolled hypertension were independently associated with developed NAF. Baseline PWPT II with cut-off ≥57.9 ms and PD ≥ 35.5 ms has high sensitivity and specificity on NAF prediction. In conclusion, baseline PWPT and PD are potential electrophysiological parameters for predicting NAF in e-HTN.

Asunto(s)

Fibrilación Atrial; Hipertensión; Humanos; Fibrilación Atrial/diagnóstico; Estudios de Casos y Controles; Electrocardiografía; Ecocardiografía; Hipertensión/complicaciones

Palabras clave

Atrial fibrillation; Hypertension; P-wave dispersion; P-wave peak time; Renin Angiotensin Aldosterone inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Hipertensión Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Hypertens Res Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Reino Unido

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