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Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
Iyer, Kali R; Li, Sheena C; Revie, Nicole M; Lou, Jennifer W; Duncan, Dustin; Fallah, Sara; Sanchez, Hiram; Skulska, Iwona; Usaj, Mojca Mattiazzi; Safizadeh, Hamid; Larsen, Brett; Wong, Cassandra; Aman, Ahmed; Kiyota, Taira; Yoshimura, Mami; Kimura, Hiromi; Hirano, Hiroyuki; Yoshida, Minoru; Osada, Hiroyuki; Gingras, Anne-Claude; Andes, David R; Shapiro, Rebecca S; Robbins, Nicole; Mazhab-Jafari, Mohammad T; Whitesell, Luke; Yashiroda, Yoko; Boone, Charles; Cowen, Leah E.
Afiliación
  • Iyer KR; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Li SC; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Revie NM; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Lou JW; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Duncan D; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Fallah S; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Sanchez H; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA.
  • Skulska I; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
  • Usaj MM; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON, Canada.
  • Safizadeh H; Department of Computer Science and Engineering and Department of Electrical and Computer Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
  • Larsen B; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
  • Wong C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
  • Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
  • Kiyota T; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Yoshimura M; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Kimura H; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Hirano H; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Yoshida M; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Osada H; RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
  • Andes DR; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA.
  • Shapiro RS; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
  • Robbins N; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Mazhab-Jafari MT; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.
  • Whitesell L; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Yashiroda Y; RIKEN Center for Sustainable Resource Science, Wako, Japan. Electronic address: ytyy@riken.jp.
  • Boone C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada; RIKEN Center for Sustainable Resource Science, Wako, Japan. Electronic address: charlie.boone@utoronto.ca.
  • Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: leah.cowen@utoronto.ca.
Cell Chem Biol ; 30(7): 795-810.e8, 2023 07 20.
Article en En | MEDLINE | ID: mdl-37369212
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Antifúngicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Antifúngicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos