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Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans.
Li, Ying; Chen, Chaoqun; Cong, Liu; Mao, Shanshan; Shan, Mingzhu; Han, Zibing; Mao, Jiayi; Xie, Zhiyu; Zhu, Zuobin.
Afiliación
  • Li Y; School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
  • Chen C; School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
  • Cong L; School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
  • Mao S; School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
  • Shan M; School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
  • Han Z; Clinical Laboratory, The Central Hospital of Xuzhou City, Xuzhou, China.
  • Mao J; Department of Genetics, Xuzhou Medical University, Xuzhou, China.
  • Xie Z; Department of Genetics, Xuzhou Medical University, Xuzhou, China.
  • Zhu Z; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, China.
Virulence ; 14(1): 2230009, 2023 12.
Article en En | MEDLINE | ID: mdl-37367101
Candidiasis caused by Candida albicans infection has long been a serious human health problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are novel targets of antifungal drugs for low risk of resistance development. In this study, we identified a maleimide compound [1-(4-methoxyphenyl)-1hydro-pyrrole-2,5-dione, MPD] that exerts effective anti-virulence activity. It could inhibit the process of adhesion, filamentation, and biofilm formation in C. albicans. In addition, it exhibited low cytotoxicity, hemolytic activity, and drug resistance development. Moreover, in Galleria mellonella-C. albicans (in vivo) infection model, the survival time of infected larvae was significantly prolonged under the treatment of MPD. Further, mechanism research revealed that MPD increased farnesol secretion by upregulating the expression of Dpp3. The increased farnesol inhibited the activity of Cdc35, which then decreased the intracellular cAMP content resulting in the inhibition of virulence factors via the Ras1-cAMP-Efg1 pathway. In all, this study evaluated the inhibitory effect of MPD on various virulence factors of C. albicans and identified the underlying mechanisms. This suggests a potential application of MPD to overcome fungal infections in clinics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Virulence Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Virulence Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos