Your browser doesn't support javascript.
loading
Role of Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Could It Be Considered a Predictor of Prognosis?
De Simoni, Ottavia; Dal Santo, Luca; Scarpa, Marco; Munari, Giada; Spolverato, Ylenia Camilla; Scapinello, Antonio; Lonardi, Sara; Soldà, Caterina; Bergamo, Francesca; Fantin, Alberto; Bardini, Romeo; Pilati, Pierluigi; Fassan, Matteo; Gruppo, Mario.
Afiliación
  • De Simoni O; Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Dal Santo L; Pathology Unit, Department of Medicine, University of Padova, 35128 Padua, Italy.
  • Scarpa M; Chirurgia Generale 3, Azienda Ospedale Università Padova, 35128 Padua, Italy.
  • Munari G; Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Spolverato YC; General Surgery Unit, Azienda Ospedaliera di Padova, 35128 Padua, Italy.
  • Scapinello A; Anatomy and Pathological Histology Unit, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Lonardi S; Unit of Medical Oncology 3, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Soldà C; Unit of Medical Oncology 1, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Bergamo F; Unit of Medical Oncology 1, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Fantin A; Gastroenterology Unit, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Bardini R; General Surgery Unit, Azienda Ospedaliera di Padova, 35128 Padua, Italy.
  • Pilati P; Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
  • Fassan M; Pathology Unit, Department of Medicine, University of Padova, 35128 Padua, Italy.
  • Gruppo M; Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy.
Curr Oncol ; 30(6): 5515-5528, 2023 06 08.
Article en En | MEDLINE | ID: mdl-37366900
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly immunosuppressive tumor microenvironment (TME). The aim of this study is to determine the potential significant TME immune markers of long-term survival. METHODS: We retrospectively included patients with a diagnosis of resectable PDAC having undergone upfront surgery. Immunohistochemical (IHC) staining using tissue microarray for PD-L1, CD3, CD4, CD8, FOXP3, CD20, iNOS and CD163 was performed in order to characterize the TME. The primary endpoint was long-term survival, defined as the Overall Survival > 24 months from surgery. RESULTS: A total of 38 consecutive patients were included, and 14 (36%) of them were long-term survivors. Long-term survivors showed a higher density of CD8+ lymphocytes intra- and peri-acinar (p = 0.08), and a higher CD8/FOXP3 intra- and peri-tumoral ratio (p = 0.05). A low density of intra- and peri-tumoral FOXP3 infiltration is a good predictor of long-term survival (p = 0.04). A significant association of the low density of intra- and peri-tumoral tumor-associated macrophages (TAMs) iNOS+ with long-term survival was detected (p = 0.04). CONCLUSIONS: Despite the retrospective nature and small sample size, our study showed that the high infiltration of CD8+ lymphocytes and low infiltration of FOXP3+ and TAMs iNOS+ are predictors of good prognosis. A preoperative assessment of these potential immune markers could be useful and determinant in the staging process and in PDAC management.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza