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Efficacy of ozone therapy on visual evoked potentials in diabetic patients.
Izadi, Morteza; Javanbakht, Mohammad; Sarafzadeh, Ali; Einollahi, Behzad; Futuhi, Farzaneh; Vahedi, Zahra; Zhao, Shi; Jonaidi-Jafari, Nematollah; Hosseini, Mahboobeh Sadat; Nejad, Javad Hosseini; Naeimi, Effat; Saadat, Seyed Hassan; Ghaleh, Hadi Esmaeili Gouvarchin; Fazel, Mozhgan; Einollahi, Zahra; Cegolon, Luca.
Afiliación
  • Izadi M; Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Javanbakht M; Nephrology and Urology Research Center, Clinical Science Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. mhmjvbt81@gmail.com.
  • Sarafzadeh A; Department of Biostatistics, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Ali_sh_1993@yahoo.com.
  • Einollahi B; Nephrology and Urology Research Center, Clinical Science Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Futuhi F; Nephrology Department, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Vahedi Z; Department of Pediatrics, School of Medicine, Hazrat-E Ali. Asghar Pediatrics Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Zhao S; JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China.
  • Jonaidi-Jafari N; Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Hosseini MS; Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Nejad JH; Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Naeimi E; Endocrinology and Metabolism Department, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Saadat SH; Behavioral Sciences Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Ghaleh HEG; Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Fazel M; Ozone CRC, BMSU, Tehran, Iran.
  • Einollahi Z; Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Cegolon L; Department of Medical, Surgical & Health Sciences, University of Trieste, Trieste, Italy.
Diabetol Metab Syndr ; 15(1): 140, 2023 Jun 26.
Article en En | MEDLINE | ID: mdl-37365632
BACKGROUND: The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this paralleled randomized controlled trial was to evaluate the impact of ozone therapy on visual pathways in diabetic patients. METHODS: Sixty patients with type 2 diabetes visiting clinics of Baqiyatallah university in Tehran (Iran) hospital were randomly assigned to two experimental groups: Group 1 (N = 30) undergoing a cycle of 20 sessions of systemic oxygen-ozone therapy in addition to standard therapy for metabolic control; Group 2 (N = 30)-serving as control-receiving only standard therapy against diabetes. The primary study endpoints were two VEP parameters; P100 wave latency and P100 amplitude at 3 months. Moreover, HbA1c levels were measured before the start of treatment and three months later as secondary study endpoint. RESULTS: All 60 patients completed the clinical trial. P100 latency significantly reduced at 3 months since baseline. No correlation was found between repeated measures of P100 wave latency and HbA1c (Pearson's r = 0.169, p = 0.291). There was no significant difference between baseline values and repeated measures of P100 wave amplitude over time in either group. No adverse effects were recorded. CONCLUSIONS: Ozone therapy improved the conduction of impulses in optic pathways of diabetic patients. The improved glycemic control following ozone therpay may not fully explain the reduction of P100 wave latency though; other mechanistic effects of ozone may be involved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Diabetol Metab Syndr Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Diabetol Metab Syndr Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido