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Kidneys recovered from brain dead cardiac arrest patients resuscitated with ECPR show similar one-year graft survival compared to other donors.
Raphalen, Jean-Herlé; Soumagnac, Tal; Blanot, Stéphane; Bougouin, Wulfran; Bourdiault, Alexandre; Vimpere, Damien; Ammar, Hatem; Dagron, Christelle; An, Kim; Mungur, Akshay; Carli, Pierre; Hutin, Alice; Lamhaut, Lionel.
Afiliación
  • Raphalen JH; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Soumagnac T; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Blanot S; Pediatric and Obstetric ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Bougouin W; INSERM U970, Team 4 "Sudden Death Expertise Center", Paris, France; Jacques Cartier Hospital, Massy, France.
  • Bourdiault A; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Vimpere D; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Ammar H; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Dagron C; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • An K; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Mungur A; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France.
  • Carli P; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France; Paris Cité University, Paris, France.
  • Hutin A; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France; INSERM U955, Team 3, Créteil, France.
  • Lamhaut L; SAMU de Paris-ICU, Necker University Hospital, Greater Paris University Hospitals, Paris, France; INSERM U970, Team 4 "Sudden Death Expertise Center", Paris, France; Paris Cité University, Paris, France. Electronic address: lionel@lamhaut.fr.
Resuscitation ; 190: 109883, 2023 09.
Article en En | MEDLINE | ID: mdl-37355090
INTRODUCTION: Among patients treated with extracorporeal cardiopulmonary resuscitation (ECPR) as a second line of treatment for refractory out-of-hospital cardiac arrest (OHCA), some may develop brain death and become eligible for organ donation. The objective of this study was to evaluate long-term outcomes of kidney grafts recovered from these patients. MATERIAL AND METHODS: We conducted a retrospective monocentric observational study between January 1, 2011, and December 31, 2017. We exclusively included patients eligible for planned donation after brainstem death and from whom at least one organ graft was retrieved and transplanted. We compared two groups of brain dead patients: those treated with ECPR for refractory OHCA (ECPR group) and a diverse group of patients who did not receive ECPR, from which only 5/23 (22%) had OHCA (control group). The primary outcome was one-year kidney graft survival. RESULTS: We included 45 patients, 23 in the control group and 22 in the ECPR group. Although patients in the ECPR group were younger and had a lower prevalence of chronic renal disease (p = 0.01), their kidney function was more severely impaired upon admission in the ICU. A total of 68 kidney grafts were retrieved, transplanted, and studied, 34 in each study group. There was no significant difference between the two groups in terms of one-year kidney graft survival (p = 0.52). CONCLUSION: Organ transplantation from patients treated with ECPR after refractory OHCA showed one-year kidney graft survival rates comparable to those of patients not treated with ECPR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxigenación por Membrana Extracorpórea / Reanimación Cardiopulmonar / Paro Cardíaco Extrahospitalario Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Resuscitation Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxigenación por Membrana Extracorpórea / Reanimación Cardiopulmonar / Paro Cardíaco Extrahospitalario Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Resuscitation Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Irlanda