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Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis.
Peng, Yundong; Wang, JiePing; Liu, Xinyao; Zhou, Yanqing; Jia, Shaohui; Xu, Jinrong; Zheng, Cheng.
Afiliación
  • Peng Y; School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
  • Wang J; Laboratory of Exercise Biochemistry, Institute of Sports Sciences, University of Taipei, Taipei, Taiwan.
  • Liu X; College of Sports Medicine, Wuhan Sports University, Wuhan, China.
  • Zhou Y; College of Sports Medicine, Wuhan Sports University, Wuhan, China.
  • Jia S; Hubei Key Laboratory of Sport Training and Monitoring, College of Sports Medicine, Wuhan Sports University, Wuhan, China.
  • Xu J; Hospital of Central China Normal University, Wuhan, China. Electronic address: 2623906475@qq.com.
  • Zheng C; Department of Sports Medicine, Affiliated Hospital, Wuhan Sports University, Wuhan, China. Electronic address: zchmily5460@126.com.
Ann Vasc Surg ; 98: 365-373, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37355015
ABSTRACT

BACKGROUND:

The probiological healing effect of platelet-rich plasma (PRP) during tissue repair has recently gathered much attention. This study aimed to conduct a systematic review and meta-analysis of patients with diabetic foot ulcer (DFU) receiving PRP or conventional treatment to evaluate their efficacy.

METHODS:

PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases were comprehensively searched by 2 independent reviewers following PRISMA guidelines for the inclusion of randomized controlled trials (RCTs) comparing PRP with conventional treatments for DFUs. The primary measurements of healing rate and healing time, the methodological quality and extracted data were assessed using Review Manager 5.3. Statistical significance was set at P < 0.05.

RESULTS:

A total of 10 RCTs involving 550 patients were included in this study, PRP was observed to significantly improve the healing rate (risk ratio [RR] = 1.38, 95% confidence interval [CI] 1.05-1.82, P = 0.02) and shorten the healing time (mean difference [MD] = -23.23, 95% CI -45.97 to -0.49, P = 0.05) of patients with DFU when compared to the conventional treatment.

CONCLUSIONS:

Compared to conventional treatment, PRP effectively promoted the healing of patients with DFU by evidently improving the healing rate and healing time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pie Diabético / Diabetes Mellitus / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Ann Vasc Surg Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pie Diabético / Diabetes Mellitus / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Ann Vasc Surg Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos