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Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis.
Figueiredo, Gerusa Maria; Tengan, Fátima Mitiko; Campos, Sergio Roberto; Luna, Expedito José.
Afiliación
  • Figueiredo GM; Departamento de Medicina Preventiva da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: gfigueiredo@usp.br.
  • Tengan FM; Departamento de Moléstias Infecciosas e Parasitarias da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: fatima.tengan@usp.br.
  • Campos SR; Departamento de Medicina Preventiva da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: srcampos@usp.br.
  • Luna EJ; Departamento de Medicina Preventiva da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: eluna@usp.br.
Clinics (Sao Paulo) ; 78: 100233, 2023.
Article en En | MEDLINE | ID: mdl-37348256
OBJECTIVES: To summarize the data on SARS-CoV-2 seroprevalence surveys conducted in Brazil before the introduction of vaccines METHODS: The authors conducted a systematic review and meta-analysis on the seroprevalence of SARS-CoV-2 infection in Brazil. The present review followed the PRISMA guidelines. The authors searched Medline, Embase, and LILACS databases for serologic surveys conducted in the Brazilian population, in the period from 01/10/2019 to 07/11/2021, without language restrictions. The authors included studies that presented data concerning SARS-CoV-2 antibodies seroprevalence in Brazil and had a sample size ≥50 individuals. Considering the expected heterogeneity between studies, all analyses were performed using the random effects model, and heterogeneity was assessed using the I2 statistic RESULTS: Of 586 publications identified in the initial searches, 54 were included in the review and meta-analysis, which contained the results of 135 surveys, with 336,620 participants. The estimated seroprevalence was 11.0%, ranging from 1.0% to 83.0%, with a substantial heterogeneity (I2 = 99.55%). In subgroup analyses, the authors observed that the prevalence of SARS-CoV-2 antibodies was 13.0% in blood donors, 9.0% in the population-based surveys, 13% in schoolchildren, and 11.0% in healthcare workers. CONCLUSIONS: Seroprevalence increases over time. Large differences were observed among the regions of the country. It was higher in the Northern region, decreasing towards the South. The present results may contribute to the analysis of the spread of SARS-CoV-2 infection in the Brazilian population before vaccination, one of the factors that may be influencing the clinical presentation of COVID-19 cases related to the new variants, as well as the effectiveness of the vaccination program.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Guideline / Prognostic_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Child / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Guideline / Prognostic_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Child / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos