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Isolation and antibacterial activity of anomanol B and other secondary metabolites from the stem bark of Anonidium mannii (Annonaceae).
Ngangoue, Marcelle Oliviane; Ndifor, Ache Roland; Ambassa, Pantaleon; Guefack, Michel-Gael F; Kuete, Jenifer R N; Chi, Godloves Fru; Ngameni, Bathelemy; Kuete, Victor; Ngadjui, Bonaventure Tchaleu.
Afiliación
  • Ngangoue MO; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Ndifor AR; Higher Technical Teachers Training College, University of Bamenda, Bambili, Cameroon.
  • Ambassa P; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Guefack MF; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Kuete JRN; Department of Chemsitry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Chi GF; Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.
  • Ngameni B; Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
  • Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Ngadjui BT; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Nat Prod Res ; : 1-10, 2023 Jun 22.
Article en En | MEDLINE | ID: mdl-37345499
A new Lanosta-7,9(11),22-trien-3,15,20-triol named Anomanol B 1, together with five known compounds: manniindole 2, arborinine 3, polycarpol 4, 8,9-dimethoxyphenanthridin-6(5H)-one 5 and 3-O-ß-D-glucopyranosyl-ß-sitosterol 6 were isolated from the stem bark extract of Anonidium mannii by routine chromatography techniques. 8,9-dimethoxyphenanthridin-6(5H)-one 5, was reported from natural origin for the first time. The structures of the compounds were established by comprehensive elucidation of spectroscopic data and by comparison with literature data. Evaluation of the isolates on Gram-negative bacteria such as Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Providencia stuartii, and Pseudomonas aeruginosa showed that, compound 1 had weak antibacterial activity with minimal inhibitory concentrations (MIC) varying from 128 to 256 µg/mL. Compounds 3, 5, and 6 exhibited moderate to weak activity with MIC of 32 to 128 µg/mL and 64 to 256 µg/mL compared to the reference drug chloramphenicol which inhibited the growth of all studied bacteria with MIC values of 16 to 64 µg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido