Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates.

Otsuka, Yukio; Poondru, Srinivasu; Bonate, Peter L; Rose, Rachel H; Jamei, Masoud; Ushigome, Fumihiko; Minematsu, Tsuyoshi

Otsuka, Yukio; Poondru, Srinivasu; Bonate, Peter L; Rose, Rachel H; Jamei, Masoud; Ushigome, Fumihiko; Minematsu, Tsuyoshi.

Afiliación

Otsuka Y; Clinical Pharmacology and Exploratory Development, Astellas Pharma Inc., 2-5-1, Nihonbashi-honcho, Chuo-ku, Tokyo, 103-8411, Japan. yukio.otsuka@astellas.com.
Poondru S; Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Bonate PL; Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA.
Rose RH; Simcyp Division, Certara UK, Sheffield, UK.
Jamei M; Simcyp Division, Certara UK, Sheffield, UK.
Ushigome F; Applied Research and Operations, Astellas Pharma Inc., Ibaraki, Japan.
Minematsu T; Immuno-oncology, Astellas Pharma Inc., Ibaraki, Japan.

J Pharmacokinet Pharmacodyn ; 50(5): 365-376, 2023 10.

Article en En | MEDLINE | ID: mdl-37344637

Asunto(s)

Citocromo P-450 CYP3A; Rivaroxabán; Masculino; Humanos; Citocromo P-450 CYP3A/metabolismo; Interacciones Farmacológicas; Preparaciones Farmacéuticas/metabolismo; Modelos Biológicos

Palabras clave

Apixaban; Drug-drug interaction (DDI); Enzalutamide; P-glycoprotein (P-gp); Physiologically-based pharmacokinetics (PBPK); Rivaroxaban

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocromo P-450 CYP3A / Rivaroxabán Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: J Pharmacokinet Pharmacodyn Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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