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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Cleghorn, Laura A T; Wall, Richard J; Albrecht, Sébastien; MacGowan, Stuart A; Norval, Suzanne; De Rycker, Manu; Woodland, Andrew; Spinks, Daniel; Thompson, Stephen; Patterson, Stephen; Corpas Lopez, Victoriano; Dey, Gourav; Collie, Iain T; Hallyburton, Irene; Kime, Robert; Simeons, Frederick R C; Stojanovski, Laste; Frearson, Julie A; Wyatt, Paul G; Read, Kevin D; Gilbert, Ian H; Wyllie, Susan.
Afiliación
  • Cleghorn LAT; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Wall RJ; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Albrecht S; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • MacGowan SA; Division of Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Norval S; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • De Rycker M; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Woodland A; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Spinks D; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Thompson S; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Patterson S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Corpas Lopez V; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Dey G; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Collie IT; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Hallyburton I; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Kime R; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Simeons FRC; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Frearson JA; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Read KD; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Wyllie S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
J Med Chem ; 66(13): 8896-8916, 2023 07 13.
Article en En | MEDLINE | ID: mdl-37343180
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Citostáticos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Citostáticos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos