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Head Kinematics, Blood Biomarkers, and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock.
Mayer, Andrew R; Dodd, Andrew B; Dodd, Rebecca J; Stephenson, David D; Ling, Josef M; Mehos, Carissa J; Patton, Declan A; Robertson-Benta, Cidney R; Gigliotti, Andrew P; Vermillion, Meghan S; Noghero, Alessio.
Afiliación
  • Mayer AR; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
  • Dodd AB; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
  • Dodd RJ; Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
  • Stephenson DD; Department of Psychology, and University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
  • Ling JM; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
  • Mehos CJ; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
  • Patton DA; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
  • Robertson-Benta CR; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
  • Gigliotti AP; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
  • Vermillion MS; Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Noghero A; The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, New Mexico, USA.
J Neurotrauma ; 40(19-20): 2205-2216, 2023 10.
Article en En | MEDLINE | ID: mdl-37341029
Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) are each leading causes of mortality and morbidity worldwide, and present additional treatment considerations when they are comorbid (TBI+HS) as a result of competing pathophysiological responses. The current study rigorously quantified injury biomechanics with high precision sensors and examined whether blood-based surrogate markers were altered in general trauma as well as post-neurotrauma. Eighty-nine sexually mature male and female Yucatan swine were subjected to a closed-head TBI+HS (40% of circulating blood volume; n = 68), HS only (n = 9), or sham trauma (n = 12). Markers of systemic (e.g., glucose, lactate) and neural functioning were obtained at baseline, and at 35 and 295 min post-trauma. Opposite and approximately twofold differences existed for both magnitude (device > head) and duration (head > device) of quantified injury biomechanics. Circulating levels of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and ubiquitin C-terminal hydrolase L1 (UCH-L1) demonstrated differential sensitivity for both general trauma (HS) and neurotrauma (TBI+HS) relative to shams in a temporally dynamic fashion. GFAP and NfL were both strongly associated with changes in systemic markers during general trauma and exhibited consistent time-dependent changes in individual sham animals. Finally, circulating GFAP was associated with histopathological markers of diffuse axonal injury and blood-brain barrier breach, as well as variations in device kinematics following TBI+HS. Current findings therefore highlight the need to directly quantify injury biomechanics with head mounted sensors and suggest that GFAP, NfL, and UCH-L1 are sensitive to multiple forms of trauma rather than having a single pathological indication (e.g., GFAP = astrogliosis).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Hemorrágico / Lesiones Traumáticas del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Hemorrágico / Lesiones Traumáticas del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos