Your browser doesn't support javascript.
loading
Vitamin D and diabetic peripheral neuropathy: A multi-centre nerve conduction study among Chinese patients with type 2 diabetes.
Pang, Chunyang; Yu, Huan; Cai, Yunlei; Song, Mengwan; Feng, Fei; Gao, Lingfei; Li, Kezheng; Chen, Yinuo; Xie, Jiali; Cheng, Yifan; Lin, Er; Pan, Xinnan; Zhang, Wanli; Deng, Binbin.
Afiliación
  • Pang C; Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Yu H; Department of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
  • Cai Y; Department of Neurology, Anyang District Hospital, Henan Province, China.
  • Song M; Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Feng F; First Clinical College of Wenzhou Medical University, Wenzhou, China.
  • Gao L; Department of Neurology, Ruian People's Hospital, Wenzhou, China.
  • Li K; Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Chen Y; First Clinical College of Wenzhou Medical University, Wenzhou, China.
  • Xie J; Department of Neurology, Shaoxing People's Hospital, Shaoxing, China.
  • Cheng Y; Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Lin E; First Clinical College of Wenzhou Medical University, Wenzhou, China.
  • Pan X; First Clinical College of Wenzhou Medical University, Wenzhou, China.
  • Zhang W; Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China.
  • Deng B; Department of Neurology, Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Diabetes Metab Res Rev ; 39(7): e3679, 2023 10.
Article en En | MEDLINE | ID: mdl-37337761
AIMS: Increasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi-centre study sought to investigate these associations based on objective quantifications. MATERIALS AND METHODS: Information on DPN-related symptoms, signs, all diabetic microvascular complications, and nerve conduction abilities (quantified by nerve conduction amplitude and velocity, F-wave minimum latency (FML) of peripheral nerves) were collected from a derivation cohort of 1192 patients with type 2 diabetes (T2D). Correlation, regression analysis, and restricted cubic splines (RCS) were used to explore linear and non-linear relationships between vitamin D and DPN, which were validated in an external cohort of 223 patients. RESULTS: Patients with DPN showed lower levels of vitamin D than those without DPN; patients with vitamin D deficiency (<30 nmol/L) tended to suffer more DPN-related neurological deficits (paraesthesia, prickling, abnormal temperature, ankle hyporeflexia, and distal pall hypoesthesia correlating with MNSI-exam score (Y = -0.005306X + 2.105, P = 0.048). Worse nerve conduction abilities (decreased motor nerve amplitude, sensory nerve amplitude, motor nerve velocity, and increased FML) were also observed in these patients. Vitamin D had a significant threshold association with DPN (adjusted OR = 4.136, P = 0.003; RCS P for non-linearity = 0.003) and correlates with other microvascular complications (diabetic retinopathy and diabetic nephropathy). CONCLUSIONS: Vitamin D is associated with the conduction ability of peripheral nerves and may have a nerve- and threshold-selective relationship with the prevalence and severity of DPN among patients with T2D.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido