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Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?
Çapkinoglu, Emir; Tufan, Aydin Eray; Ömeroglu, Sinan; Tanal, Mert; Güven, Onur; Demir, Uygar.
Afiliación
  • Çapkinoglu E; Department of General Surgery, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.
  • Tufan AE; Department of General Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
  • Ömeroglu S; Department of General Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
  • Tanal M; Department of General Surgery, Tekirdag Ismail Fehmi Cumalioglu MD City Hospital, Tekirdag, Turkey.
  • Güven O; Department of General Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
  • Demir U; Department of General Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
Medicine (Baltimore) ; 102(20): e33757, 2023 May 19.
Article en En | MEDLINE | ID: mdl-37335735
Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos