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Human polyomavirus BKPyV and JCPyV serostatus has no impact on women´s human papillomavirus infection outcome.
Laine, Hanna K; Waterboer, Tim; Syrjänen, Kari; Grenman, Seija; Louvanto, Karolina; Syrjänen, Stina.
Afiliación
  • Laine HK; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
  • Waterboer T; Department of Oral Pathology and Radiology, Faculty of Medicine, University of Turku, Turku, Finland.
  • Syrjänen K; Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Grenman S; SMW Consultants Ltd, Kaarina, Finland.
  • Louvanto K; Department of Obstetrics and Gynecology, University of Turku, Turku University Hospital, Turku, Finland.
  • Syrjänen S; Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Front Cell Infect Microbiol ; 13: 1190019, 2023.
Article en En | MEDLINE | ID: mdl-37333846
Introduction: Polyomaviruses have both structural and functional similarities with papillomaviruses. Accordingly, their role in human papillomavirus (HPV) associated malignancies has been studied with conflicting results. Our goal was to disclose any association between BK (BKPyV) and/or JC (JCPyV) polyomavirus serology and HPV data derived from Finnish women (327) in a 6-year prospective follow-up. Methods: Glutathione S-transferase fusion-protein-capture (ELISA) in combination with fluorescent bead technology was used to analyze antibodies to BKPyV and JCPyV. In the longitudinal setting, BKPyV or JCPyV serostatus was related to i) oral- and ii) genital low (LR)- and high risk (HR) HPV DNA detection, iii) HPV16 persistence at both these sites, iv) results of the Pap (Papanicolaou) smear taken at baseline, and v) development of incident CIN (cervical intraepithelial neoplasia) during the follow-up. Results: Being BKPyV or JCPyV seropositive was not significantly associated with HPV seropositivity to either LR- or HR-genotypes, genital- or oral HPV DNA positivity, persistence of genital- or oral HPV16 infection, grade of Pap smear, or development of incident CIN. Discussion: Thus, the present study could not provide any confirmation to the concept that co-infections by HPyV and HPV have interactions that impact on the clinical manifestations or outcomes of HPV infections either in the genital tract or in the oral mucosa.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Poliomavirus / Infecciones por Papillomavirus Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Poliomavirus / Infecciones por Papillomavirus Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza