Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Bowles, K R; Pugh, D A; Pedicone, C; Oja, L; Weitzman, S A; Liu, Y; Chen, J L; Disney, M D; Goate, A M

Bowles, K R; Pugh, D A; Pedicone, C; Oja, L; Weitzman, S A; Liu, Y; Chen, J L; Disney, M D; Goate, A M.

Afiliación

Bowles KR; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Pugh DA; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Pedicone C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Oja L; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Weitzman SA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Liu Y; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Chen JL; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Disney MD; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

bioRxiv ; 2023 Jun 05.

Article en En | MEDLINE | ID: mdl-37333200

Palabras clave

4R tau; Astrocytes; Inflammation; MAPT; Mitochondria; Splicing; Synapses

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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