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Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.
Zerrad, Chaimaa; Lkhider, Mustapha; Belkouchi, Abdelkader; Tanouti, Ikram-Allah; Badre, Wafaa; Tahiri, Mohamed; Ayassi, Sarra; Marchio, Agnès; Pineau, Pascal; Benjelloun, Soumaya; Ezzikouri, Sayeh.
Afiliación
  • Zerrad C; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
  • Lkhider M; Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, University Hassan II Casablanca Faculty des Sciences Techniques, Mohammedia, Morocco.
  • Belkouchi A; Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, University Hassan II Casablanca Faculty des Sciences Techniques, Mohammedia, Morocco.
  • Tanouti IA; CHU Ibn Sina, Médecine A, Rabat, Morocco.
  • Badre W; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
  • Tahiri M; CHU Ibn Rochd, Médecine B, Casablanca, Morocco.
  • Ayassi S; CHU Ibn Rochd, Médecine B, Casablanca, Morocco.
  • Marchio A; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
  • Pineau P; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
  • Benjelloun S; Unité "Organisation Nucléaire et Oncogenèse", INSERM U993, Institut Pasteur, Paris, France.
  • Ezzikouri S; Unité "Organisation Nucléaire et Oncogenèse", INSERM U993, Institut Pasteur, Paris, France.
Nucleosides Nucleotides Nucleic Acids ; 42(12): 986-1003, 2023.
Article en En | MEDLINE | ID: mdl-37330637
Hepatocellular carcinoma (HCC) is the fifth most common human malignancy and the fourth most frequent cause of cancer-related deaths worldwide. Toll-like receptors (TLRs), are known to play a key role in hepatocarcinogenesis through induction of inflammation. We aimed to investigate the association between TLR2 rs3804099, TLR4 rs4986790, rs4986791, and rs11536889 and TLR5 rs5744174 and HCC risk in a total of 306 Moroccan subjects, including 152 HCC patient and 154 controls using a TaqMan allelic discrimination assay. Our result showed that the frequency of TLR4 rs11536889 C allele was higher in control group than in HCC patients (OR = 0.52, 95% CI = 0.30-0.88, p = 0.01). Moreover, under the dominant model, we observed that CG/CC genotypes were protective factors against HCC risk (OR = 0.51, 95% CI = 0.28-0.91, p = 0.02). However, no significant differences were found in the allele and genotype frequencies of TLR4 rs4986790 and rs4986791, between HCC patients and controls. Similarly, genotypic frequencies of TLR2 and TLR5 polymorphisms did not differ significantly between HCC patients and controls. However, TLR4 haplotype analysis revealed that ACC haplotype may be protective of HCC risk in patients with HCC (OR = 0.53, 95% CI = 0.31-0.92, p = 0.02). In conclusion, our result suggest that TLR4 rs11536889 polymorphism and ACC haplotype may decrease risk of hepatocellular carcinoma in Moroccan population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nucleosides Nucleotides Nucleic Acids Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nucleosides Nucleotides Nucleic Acids Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos