Your browser doesn't support javascript.
loading
Amniotic fluid metabolomics identifies impairment of glycerophospholipid and amino acid metabolism during congenital Zika syndrome development.
Sosa-Acosta, Patricia; Evaristo, Geisa P C; Evaristo, Joseph A M; Carneiro, Gabriel Reis Alves; Quiñones-Vega, Mauricio; Monnerat, Gustavo; Melo, Adriana; Garcez, Patrícia P; Nogueira, Fábio C S; Domont, Gilberto B.
Afiliación
  • Sosa-Acosta P; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Evaristo GPC; Laboratory of Proteomics, LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Evaristo JAM; Precision Medicine Research Center, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Carneiro GRA; Center of Applied Biomolecular Studies in Healthy, Osvaldo Cruz Foundation Unit of Rondônia, Porto Velho, Rondonia, Brazil.
  • Quiñones-Vega M; Center of Applied Biomolecular Studies in Healthy, Osvaldo Cruz Foundation Unit of Rondônia, Porto Velho, Rondonia, Brazil.
  • Monnerat G; Laboratory of Proteomics, LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Melo A; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Garcez PP; Laboratory of Proteomics, LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Nogueira FCS; Precision Medicine Research Center, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Domont GB; Precision Medicine Research Center, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Proteomics Clin Appl ; 18(1): e2300008, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37329193
PURPOSE: Our main goal is to identify the alterations in the amniotic fluid (AF) metabolome in Zika virus (ZIKV)-infected patients and their relation to congenital Zika syndrome (CZS) progression. EXPERIMENTAL DESIGN: We applied an untargeted metabolomics strategy to analyze seven AF of pregnant women: healthy women and ZIKV-infected women bearing non-microcephalic and microcephalic fetuses. RESULTS: Infected patients were characterized by glycerophospholipid metabolism impairment, which is accentuated in microcephalic phenotypes. Glycerophospholipid decreased concentration in AF can be a consequence of intracellular transport of lipids to the placental or fetal tissues under development. The increased intracellular concentration of lipids can lead to mitochondrial dysfunction and neurodegeneration caused by lipid droplet accumulation. Furthermore, the dysregulation of amino acid metabolism was a molecular fingerprint of microcephalic phenotypes, specifically serine, and proline metabolisms. Both amino acid deficiencies were related to neurodegenerative disorders, intrauterine growth retardation, and placental abnormalities. CONCLUSIONS AND CLINICAL RELEVANCE: This study enhances our understanding of the development of CZS pathology and sheds light on dysregulated pathways that could be relevant for future studies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Virus Zika / Infección por el Virus Zika / Microcefalia Límite: Female / Humans / Pregnancy Idioma: En Revista: Proteomics Clin Appl Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Virus Zika / Infección por el Virus Zika / Microcefalia Límite: Female / Humans / Pregnancy Idioma: En Revista: Proteomics Clin Appl Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania