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Body Mass Index Trajectories and Biomarkers of Cardiometabolic Risk in Children from Low-Income and Racially and Ethnically Diverse Households.
de Brito, Junia N; Pereira, Mark A; Kelly, Aaron S; Erickson, Darin J; Sherwood, Nancy E; Mason, Susan M; Loth, Katie A; French, Simone A; Evanoff, Nicholas G; Dengel, Donald R; Kunin-Batson, Alicia S.
Afiliación
  • de Brito JN; Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Pereira MA; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Kelly AS; Center for Pediatric Obesity Medicine, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Erickson DJ; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Sherwood NE; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Mason SM; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Loth KA; Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN, USA.
  • French SA; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Evanoff NG; Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Dengel DR; School of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
  • Kunin-Batson AS; Center for Pediatric Obesity Medicine, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Child Obes ; 2023 Jun 15.
Article en En | MEDLINE | ID: mdl-37327058
Background: This study examined the associations between BMI trajectories and emerging cardiometabolic risk (CMR) in children living in low-income and racially and ethnically diverse households in the United States. Methods: Data were drawn from NET-Works randomized intervention trial and NET-Works 2 prospective follow-up study (N = 338). BMI was measured across 6 follow-up visits and biomarkers of cardiometabolic risk (CMR) at the sixth visit. Group-based trajectory modeling identified child BMI trajectories. Adjusted multivariable linear regressions evaluated the associations between BMI trajectories and CMR. Results: We identified two BMI trajectories: 25% followed a trajectory of steep BMI increase, and 75% followed a moderate decreasing BMI trajectory over time. Relative to children in the moderate decreasing trajectory, children in the increasing trajectory had higher adjusted mean levels of C-reactive protein [CRP; 3.3; 95% confidence interval (CI): 1.6 to 5.0], leptin (63.1; 95% CI: 44.3 to 81.8), triglycerides (35.4; 95% CI: 22.1 to 48.6), triglyceride/high-density lipoprotein (HDL) ratio (1.2; 95% CI: 0.8 to 1.6), hemoglobin A1c (HbA1C; 0.1; 95% CI: 0.03 to 0.2), fasting glucose (1.8; 0.1 to 3.5) and insulin (8.8; 95% CI: 6.5 to 11.0), overall CMR score (0.7; 95% CI: 0.5 to 0.9), and lower adiponectin (-1.3; 95% CI: -2.5 to -0.1) and HDL (-10.8; 95% CI: -14.3 to -7.4). Conclusions: Children with high BMIs early in childhood were more likely to maintain an accelerated BMI trajectory throughout childhood, which was associated with adverse CMR in pre-adolescence. To advance health equity and support children's healthy weight and cardiovascular health trajectories, public health efforts are needed to address persistent disparities in childhood obesity and CMR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Idioma: En Revista: Child Obes Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Idioma: En Revista: Child Obes Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos