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Reproduction patterns among non-Hodgkin lymphoma survivors by subtype in Sweden, Denmark and Norway: A population-based matched cohort study.
Entrop, Joshua P; Weibull, Caroline E; Smedby, Karin E; Jakobsen, Lasse H; Øvlisen, Andreas K; Glimelius, Ingrid; Marklund, Anna; Larsen, Thomas S; Holte, Harald; Fosså, Alexander; Smeland, Knut B; El-Galaly, Tarec C; Eloranta, Sandra.
Afiliación
  • Entrop JP; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Weibull CE; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Smedby KE; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Jakobsen LH; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
  • Øvlisen AK; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Glimelius I; Department of Mathematical Science, Aalborg University, Aalborg, Denmark.
  • Marklund A; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Larsen TS; Department of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University, Uppsala, Sweden.
  • Holte H; Division of Gynecology and Reproduction, Department of Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Fosså A; Department of Hematology, Odense University Hospital, Odense, Denmark.
  • Smeland KB; Department of Oncology, Oslo University Hospital, Oslo, Norway.
  • El-Galaly TC; K.G. Jebsen Centre for B Cell Malignancies, University of Oslo, Oslo, Norway.
  • Eloranta S; Department of Oncology, Oslo University Hospital, Oslo, Norway.
Br J Haematol ; 202(4): 785-795, 2023 08.
Article en En | MEDLINE | ID: mdl-37325886
Previous studies concerning reproductive patterns among non-Hodgkin lymphoma (NHL) survivors are scarce and those available have reported conflicting results. Treatment regimens vary considerably between aggressive and indolent NHL and studies of reproductive patterns by subtypes are warranted. In this matched cohort study, we identified all NHL patients aged 18-40 years and diagnosed between 2000 and 2018 from the Swedish and Danish lymphoma registers, and the clinical database at Oslo University Hospital (n = 2090). Population comparators were matched on sex, birth year and country (n = 19 427). Hazard ratios (HRs) were estimated using Cox regression. Males and females diagnosed with aggressive lymphoma subtypes had lower childbirth rates (HRfemale : 0.43, 95% CI: 0.31-0.59, HRmale : 0.61, 95% CI: 0.47-0.78) than comparators during the first 3 years after diagnosis. For indolent lymphomas, childbirth rates were not significantly different from comparators (HRfemale : 0.71, 95% CI: 0.48-1.04, HRmale : 0.94, 95% CI: 0.70-1.27) during the same period. Childbirth rates reached those of comparators for all subtypes after 3 years but the cumulative incidence of childbirths was decreased throughout the 10-year follow-up for aggressive NHL. Children of NHL patients were more likely to be born following assisted reproductive technology than those of comparators, except for male indolent lymphoma patients. In conclusion, fertility counselling is particularly important for patients with aggressive NHL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido