Your browser doesn't support javascript.
loading
WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy.
Lin, Chia-Yen; Wang, Chun-Li; Wang, Shian-Shiang; Yang, Cheng-Kuang; Li, Jian-Ri; Chen, Chuan-Shu; Hung, Sheng-Chun; Chiu, Kun-Yuan; Cheng, Chen-Li; Ou, Yen-Chuan; Yang, Shun-Fa.
Afiliación
  • Lin CY; Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Wang CL; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • Wang SS; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Yang CK; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • Li JR; Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chen CS; Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Hung SC; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • Chiu KY; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan.
  • Cheng CL; Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Ou YC; Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Yang SF; Department of Medicine and Nursing, Hungkuang University, Taichung, Taiwan.
Int J Med Sci ; 20(7): 969-975, 2023.
Article en En | MEDLINE | ID: mdl-37324196
The downregulation of WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the tumorigenesis and poor prognosis of various cancers. In this study, we investigated the associations between the polymorphisms of WWOX, clinicopathologic features of prostate cancer (PCa), and risk of postoperative biochemical recurrence (BCR). We evaluated the effects of five single-nucleotide polymorphisms (SNPs) of WWOX on the clinicopathologic features of 578 patients with PCa. The risk of postoperative BCR was 2.053-fold higher in patients carrying at least one "A" allele in WWOX rs12918952 than in those with homozygous G/G. Furthermore, patients with at least one polymorphic "T" allele in WWOX rs11545028 had an elevated (1.504-fold) risk of PCa with seminal vesicle invasion. In patients with postoperative BCR, the risks of an advanced Gleason grade and clinical metastasis were 3.317- and 5.259-fold higher in patients carrying at least one "G" allele in WWOX rs3764340 than in other patients. Our findings indicate the WWOX SNPs are significantly associated with highly aggressive pathologic features of PCa and an elevated risk of post-RP biochemical recurrence.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Vesículas Seminales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Vesículas Seminales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Australia