Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPAR&#945; axis in vivo and in vitro.

Qiu, Ling; Feng, Ruibing; Wu, Qiu-Shuang; Wan, Jian-Bo; Zhang, Qing-Wen

Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in vivo and in vitro.

Qiu, Ling; Feng, Ruibing; Wu, Qiu-Shuang; Wan, Jian-Bo; Zhang, Qing-Wen.

Afiliación

Qiu L; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, Taipa, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, China.
Feng R; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, Taipa, China.
Wu QS; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, Taipa, China; Cancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, Taipa, China.
Wan JB; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, Taipa, China. Electronic address: jbwan@um.edu.mo.
Zhang QW; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, Taipa, China. Electronic address: qwzhang@um.edu.mo.

J Ethnopharmacol ; 317: 116785, 2023 Dec 05.

Article en En | MEDLINE | ID: mdl-37321425

Asunto(s)

Hígado Graso; Hepatopatías Alcohólicas; Panax; Saponinas; Ratones; Animales; Antioxidantes/farmacología; Especies Reactivas de Oxígeno/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; PPAR alfa/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Saponinas/farmacología; Saponinas/uso terapéutico; Saponinas/metabolismo; Ratones Endogámicos C57BL; Estrés Oxidativo; Hígado; Hígado Graso/tratamiento farmacológico; Hepatopatías Alcohólicas/tratamiento farmacológico; Hepatopatías Alcohólicas/prevención & control; Etanol/farmacología

Palabras clave

Anti-inebriation; Antioxidation; Hepatosteatosis; Panax japonicus (T. Nees) C.A. Mey.; Saponin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Hígado Graso / Panax / Hepatopatías Alcohólicas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

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