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Type 1 Cryoglobulinemic Vasculitis Due to Monoclonal Gammopathy of Undetermined Significance Successfully Treated by Bortezomib Plus Dexamethasone.
Kikuchi, Ryo; Onozawa, Masahiro; Nagai, Jun; Okada, Satomi; Hasegawa, Yuta; Ohigashi, Hiroyuki; Mitamura, Shintaro; Maeda, Taku; Takakuwa, Emi; Fujieda, Yuichiro; Goto, Hideki; Hashimoto, Daigo; Matsuno, Yoshihiro; Teshima, Takanori.
Afiliación
  • Kikuchi R; Department of Hematology, Hokkaido University Hospital, Japan.
  • Onozawa M; Department of Hematology, Hokkaido University Hospital, Japan.
  • Nagai J; Department of Hematology, Hokkaido University Hospital, Japan.
  • Okada S; Department of Hematology, Hokkaido University Hospital, Japan.
  • Hasegawa Y; Department of Hematology, Hokkaido University Hospital, Japan.
  • Ohigashi H; Department of Hematology, Hokkaido University Hospital, Japan.
  • Mitamura S; Division of Plastic Surgery, Hokkaido University Hospital, Japan.
  • Maeda T; Division of Plastic Surgery, Hokkaido University Hospital, Japan.
  • Takakuwa E; Department of Surgical Pathology, Hokkaido University Hospital, Japan.
  • Fujieda Y; Department of Rheumatology and Nephrology, Hokkaido University Hospital, Japan.
  • Goto H; Department of Hematology, Hokkaido University Hospital, Japan.
  • Hashimoto D; Department of Hematology, Hokkaido University Hospital, Japan.
  • Matsuno Y; Department of Surgical Pathology, Hokkaido University Hospital, Japan.
  • Teshima T; Department of Hematology, Hokkaido University Hospital, Japan.
Intern Med ; 63(4): 541-545, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-37316269
Cryoglobulins are immunoglobulins that precipitate in cold conditions. Type I cryoglobulinemic vasculitis is associated with hematological malignancies. We herein report a case of steroid-resistant type 1 cryoglobulinemic vasculitis associated with monoclonal gammopathy of undetermined significance (MGUS) in a 47-year-old woman. By immunofixation of cryoglobulin, we found that the main component of cryoglobulin was the M protein due to MGUS, so treatment of MGUS was needed. Bortezomib+dexamethasone therapy resulted in a rapid decrease in cryoglobulin and improvement in the symptoms of cryoglobulinemic vasculitis. In refractory type I cryoglobulinemic vasculitis, treatment of the underlying gammaglobulinopathy should be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraproteinemias / Vasculitis / Gammopatía Monoclonal de Relevancia Indeterminada / Crioglobulinemia Límite: Female / Humans / Middle aged Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraproteinemias / Vasculitis / Gammopatía Monoclonal de Relevancia Indeterminada / Crioglobulinemia Límite: Female / Humans / Middle aged Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón