Total Synthesis of Nagelamide W.

George, Dare E; Tepe, Jetze J

George, Dare E; Tepe, Jetze J.

Afiliación

George DE; Department of Chemistry, Michigan State University, East Lansing, Michigan 48823, United States.
Tepe JJ; Department of Chemistry, Michigan State University, East Lansing, Michigan 48823, United States.

J Org Chem ; 88(13): 9306-9312, 2023 07 07.

Article en En | MEDLINE | ID: mdl-37314002

RESUMEN

Herein, we report the total synthesis of nagelamide W (1), a pyrrole imidazole alkaloid of the nagelamide family isolated in 2013. The key approach in this work involves the construction of the 2-aminoimidazoline core of nagelamide W from alkene 6 through a cyanamide bromide intermediate. The synthesis of nagelamide W was accomplished with an overall yield of 6.0%.

Asunto(s)

Alcaloides; Pirroles; Estructura Molecular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Alcaloides Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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