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Inflammatory ultrasound features as prognostic factors of pain and functional outcomes following intra-articular platelet-rich plasma in knee osteoarthritis.
Oo, Win Min; Linklater, James; Bennell, Kim L; Yu, Shirley P; Duong, Vicky; Hunter, David J.
Afiliación
  • Oo WM; Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.
  • Linklater J; Department of Physical Medicine and Rehabilitation, Mandalay General Hospital, University of Medicine, Mandalay, Mandalay, Myanmar.
  • Bennell KL; Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Centre, St. Leonards, Sydney, New South Wales, Australia.
  • Yu SP; Department of Physiotherapy, Centre for Health, Exercise and Sports Medicine, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
  • Duong V; Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.
  • Hunter DJ; Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.
Int J Rheum Dis ; 26(8): 1540-1546, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37309612
AIM: To explore inflammatory ultrasound predictors of improvements in pain and function over 2, 6, and 12 months following administration of intra-articular platelet-rich plasma (PRP) in knee osteoarthritis (OA). METHOD: Patients with painful mild-moderate radiographic knee OA from a subset of the RESTORE RCT underwent ultrasound assessment according to the standardized OMERACT scanning protocol to detect inflammatory features such as synovitis, synovial hypertrophy, and effusion with power Doppler. The study knee was treated with 3 once-weekly PRP injections obtained after centrifugation at 1500 g for 5 min. Numerical Rating Score (NRS), Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire, and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) function sub-score were used to measure pain and functional severity. Separate linear regression models were performed to determine whether baseline ultrasound-detected features of inflammation predicted the improvement in pain and function following PRP injection in both unadjusted and adjusted models for confounders. RESULTS: Forty-four participants were included, with 25 (56.8%) being female. In an unadjusted model, higher OMERACT scores for inflammatory features such as global synovitis and/or effusion were significantly associated with greater improvement in all outcomes measured at 2 months but not at 6 and 12 months for pain measures. Only global synovitis showed significant association with functional improvement at 2 and 12 months. Similar findings were observed in the adjusted model. CONCLUSION: Ultrasound indices of knee inflammation predicted short-term improvements in pain severity and both short- and longer-term improvements in function following intra-articular PRP injection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinovitis / Osteoartritis de la Rodilla / Plasma Rico en Plaquetas / Dolor Crónico Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinovitis / Osteoartritis de la Rodilla / Plasma Rico en Plaquetas / Dolor Crónico Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido