Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats.
Brain Res
; 376(2): 351-6, 1986 Jun 25.
Article
en En
| MEDLINE
| ID: mdl-3730840
Axotomy of cholinergic neurons in the medial septum-diagonal band and degeneration of their terminals in the hippocampus resulting from fornix-fimbria lesions induce elevation of NGF content in these two brain regions. Postlesion levels of cholinergic neuron-specific ChAT activity in the septum suggest that endogenously produced NGF may, at least partly, promote survival of axotomized cholinergic neurons or induce ChAT activity in undamaged cells or both. These findings thus support the proposed trophic role for NGF in central cholinergic neurons.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tabique Pelúcido
/
Hipocampo
/
Factores de Crecimiento Nervioso
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Países Bajos