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Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk.
Kuiper, Lieke M; Polinder-Bos, Harmke A; Bizzarri, Daniele; Vojinovic, Dina; Vallerga, Costanza L; Beekman, Marian; Dollé, E T; Ghanbari, Mohsen; Voortman, Trudy; Reinders, Marcel J T; Verschuren, W M Monique; Slagboom, P Eline; van den Akker, Erik B; van Meurs, Joyce B J.
Afiliación
  • Kuiper LM; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Polinder-Bos HA; Center for Nutrition, Prevention and Health Services, Bilthoven, The Netherlands.
  • Bizzarri D; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Vojinovic D; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
  • Vallerga CL; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands.
  • Beekman M; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
  • Dollé ET; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Ghanbari M; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Voortman T; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
  • Reinders MJT; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
  • Verschuren WMM; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Slagboom PE; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • van den Akker EB; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
  • van Meurs JBJ; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
J Gerontol A Biol Sci Med Sci ; 78(10): 1753-1762, 2023 10 09.
Article en En | MEDLINE | ID: mdl-37303208
Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we compared epigenetic (DNAm Horvath, DNAm Hannum, DNAm Lin, DNAm epiTOC, DNAm PhenoAge, DNAm DunedinPoAm, DNAm GrimAge, and DNAm Zhang) and metabolomic-based (MetaboAge and MetaboHealth) biomarkers in reflection of biological age, as represented by 5 frailty measures and overall mortality. Biomarkers trained on outcomes with biophysiological and/or mortality information outperformed age-trained biomarkers in frailty reflection and mortality prediction. DNAm GrimAge and MetaboHealth, trained on mortality, showed the strongest association with these outcomes. The associations of DNAm GrimAge and MetaboHealth with frailty and mortality were independent of each other and of the frailty score mimicking clinical geriatric assessment. Epigenetic, metabolomic, and clinical biological age markers seem to capture different aspects of aging. These findings suggest that mortality-trained molecular markers may provide novel phenotype reflecting biological age and strengthen current clinical geriatric health and well-being assessment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos