Your browser doesn't support javascript.
loading
Type IV Hypersensitivity Reaction after Cyanoacrylate Venous Closure.
O'Banion, Leigh Ann A; Shao, Michael Y; Ali, Amna; Kochubey, Mariya; Yan, Yueqi; Fallentine, Joshua; Oh, Jae Hak; Patel, Harik R; Agrawal, Nishant; Carmona, Emely; Hager, Eric S; Kiguchi, Misaki M.
Afiliación
  • O'Banion LAA; Division of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA. Electronic address: Leighann.o'banion@ucsf.edu.
  • Shao MY; Division of Vascular Surgery, Northshore University Health System, Chicago, IL.
  • Ali A; Division of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA.
  • Kochubey M; Division of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno, Fresno, CA.
  • Yan Y; University of California Merced, Merced, CA.
  • Fallentine J; Georgetown University School of Medicine, Washington, DC.
  • Oh JH; Georgetown University School of Medicine, Washington, DC.
  • Patel HR; St. George's University of London, London, UK.
  • Agrawal N; Division of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Carmona E; Division of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Hager ES; Division of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Kiguchi MM; Department of Vascular Surgery, MedStar Washington Hospital Center, Washington, DC.
Ann Vasc Surg ; 95: 218-223, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37301253
BACKGROUND: Nonthermal endovenous closure techniques are routinely utilized to treat superficial axial venous reflux. Cyanoacrylate closure is a safe and effective modality implemented for truncal closure. However, an adverse reaction of type IV hypersensitivity (T4H), unique to cyanoacrylate, is a known risk. This study aims to evaluate the real-world incidence of T4H and examine risk factors that may predispose its development. METHODS: A retrospective review between 2012- and 2022 was performed at four tertiary US institutions to examine patients who underwent cyanoacrylate vein closure of their saphenous veins. Patient demographics, comorbidities, CEAP (Clinical [C], Etiological [E], Anatomical [A], and Pathophysiological [P]) classification, and periprocedural outcomes were included. The primary endpoint was development of T4H post procedure. Logistic regression analysis for risk factors predictive of T4H was performed. Variables with a P-value of <0.05 were deemed significant. RESULTS: 595 patients underwent 881 cyanoacrylate venous closures. Mean age was 66.2 ± 14.9, and 66% of patients were female. There were 92 (10.4%) T4H events in 79 (13%) patients. Oral steroids were administered to 23% for persistent and/or severe symptoms. There were no systemic allergic reactions to cyanoacrylate. Multivariate analysis revealed younger age (P = 0.015), active smoking status (P = 0.033), and CEAP 3 (P < 0.001) and 4 (P = 0.005) classifications as independent risk factors associated with development of T4H. CONCLUSIONS: This real-world multicenter study shows the overall incidence of T4H to be 10%. CEAP 3 and 4 patients of younger age and smokers predicted a higher risk of T4H to cyanoacrylate.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Várices / Insuficiencia Venosa / Hipersensibilidad Tardía Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Vasc Surg Asunto de la revista: ANGIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Várices / Insuficiencia Venosa / Hipersensibilidad Tardía Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Vasc Surg Asunto de la revista: ANGIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos