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Beyond Natural Immune Repertoires: Synthetic Antibodies.
Veggiani, Gianluca; Sidhu, Sachdev S.
Afiliación
  • Veggiani G; The Anvil Institute, Kitchener, Ontario N2G 1H6, Canada.
  • Sidhu SS; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
Cold Spring Harb Protoc ; 2024(4): pdb.top107768, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-37295822
Synthetic antibody libraries, in which the antigen-binding sites are precisely designed, offer unparalleled precision in antibody engineering, exceeding the potential of natural immune repertoires and constituting a novel generation of research tools and therapeutics. Recent advances in artificial intelligence-driven technologies and their integration into synthetic antibody discovery campaigns hold the promise to further streamline and effectively develop antibodies. Here, we provide an overview of synthetic antibodies. Our associated protocol describes how to develop highly diverse and functional synthetic antibody phage display libraries.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inteligencia Artificial / Biblioteca de Péptidos Tipo de estudio: Guideline Idioma: En Revista: Cold Spring Harb Protoc Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inteligencia Artificial / Biblioteca de Péptidos Tipo de estudio: Guideline Idioma: En Revista: Cold Spring Harb Protoc Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos