IL-17 induces non-small cell lung cancer metastasis via GCN5-dependent SOX4 acetylation enhancing MMP9 gene transcription and expression.

Ge, Wen; Gong, Yajuan; Li, Ya; Wu, Ningxia; Ruan, Yuting; Xu, Tongpeng; Shu, Yongqian; Qiu, Wen; Wang, Yingwei; Zhao, Chenhui

Ge, Wen; Gong, Yajuan; Li, Ya; Wu, Ningxia; Ruan, Yuting; Xu, Tongpeng; Shu, Yongqian; Qiu, Wen; Wang, Yingwei; Zhao, Chenhui.

Afiliación

Ge W; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Gong Y; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Li Y; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Wu N; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Ruan Y; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Xu T; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Shu Y; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Qiu W; Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Wang Y; Key Laboratory of Immunological Environment and Disease, Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu, China.
Zhao C; Key Laboratory of Antibody Technology of Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu, China.

Mol Carcinog ; 62(9): 1399-1416, 2023 09.

Article en En | MEDLINE | ID: mdl-37294072

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Animales; Ratones; Carcinoma de Pulmón de Células no Pequeñas/patología; Neoplasias Pulmonares/patología; Metaloproteinasa 9 de la Matriz/genética; Metaloproteinasa 9 de la Matriz/metabolismo; Interleucina-17/genética; Interleucina-17/metabolismo; Acetilación; Ratones Desnudos; Movimiento Celular/genética; Transcripción Genética; Regulación Neoplásica de la Expresión Génica; Línea Celular Tumoral; Proliferación Celular/genética

Palabras clave

GCN5; IL-17; MMP9; NSCLC metastasis; SOX4; acetylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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