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Essential role of bromodomain proteins in renal cell carcinoma (Review).
Wen, Qianghai; Liu, Haicheng; Lou, Kecheng; Zhang, Xing; Chao, Wei; Xin, Jianhui; Gong, Jiaxiang; Zou, Junrong; Zou, Xiaofeng.
Afiliación
  • Wen Q; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Liu H; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Lou K; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Zhang X; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Chao W; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Xin J; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Gong J; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Zou J; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
  • Zou X; Department of Urology, The First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
Mol Med Rep ; 28(1)2023 07.
Article en En | MEDLINE | ID: mdl-37293842
Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on bromodomain family proteins in RCC are limited and the roles of bromodomain family proteins in RCC have remained to be fully elucidated. The present review discussed the role of bromodomain family proteins in RCC, aiming to explore possible potential therapeutic targets of BRD­related drugs in this type of cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Límite: Humans Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Límite: Humans Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article Pais de publicación: Grecia