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Micromagnetic Stimulation (µMS) Controls Dopamine Release: An in vivo Study Using WINCS Harmoni.
Saha, Renata; Goyal, Abhinav; Yuen, Jason; Oh, Yoonbae; Bloom, Robert P; Benally, Onri J; Wu, Kai; Netoff, Theoden I; Low, Walter C; Bennet, Kevin E; Lee, Kendall H; Shin, Hojin; Wang, Jian-Ping.
Afiliación
  • Saha R; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States.
  • Goyal A; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Yuen J; Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States.
  • Oh Y; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Bloom RP; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong VIC 3216, Australia.
  • Benally OJ; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Wu K; Department of Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
  • Netoff TI; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States.
  • Low WC; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States.
  • Bennet KE; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States.
  • Lee KH; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.
  • Shin H; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States.
  • Wang JP; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
bioRxiv ; 2023 May 25.
Article en En | MEDLINE | ID: mdl-37292985
Objective: Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the in vivo changes in the neurochemistry that occur in real time during disease progression, drug interactions or response to pharmacological, cognitive, behavioral, and neuromodulation therapies. In this work, we used the WINCS Harmoni tool to study the real time in vivo changes in dopamine release in rodent brains for the micromagnetic neuromodulation therapy. Approach: Although still in its infancy, micromagnetic stimulation (µMS) using micro-meter sized coils or microcoils (µcoils) has shown incredible promise in spatially selective, galvanic contact free and highly focal neuromodulation. These µcoils are powered by a time-varying current which generates a magnetic field. As per Faraday's Laws of Electromagnetic Induction, this magnetic field induces an electric field in a conducting medium (here, the brain tissues). We used a solenoidal-shaped µcoil to stimulate the medial forebrain bundle (MFB) of the rodent brain in vivo. The evoked in vivo dopamine releases in the striatum were tracked in real time by carbon fiber microelectrodes (CFM) using fast scan cyclic voltammetry (FSCV). Results: Our experiments report that µcoils can successfully activate the MFB in rodent brains, triggering dopamine release in vivo. We further show that the successful release of dopamine upon micromagnetic stimulation is dependent on the orientation of the µcoil. Furthermore, varied intensities of µMS can control the concentration of dopamine releases in the striatum. Significance: This work helps us better understand the brain and its conditions arising from a new therapeutic intervention, like µMS, at the level of neurotransmitter release. Despite its early stage, this study potentially paves the path for µMS to enter the clinical world as a precisely controlled and optimized neuromodulation therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos