Your browser doesn't support javascript.
loading
Narrative Review of Multidisciplinary Management of Central Nervous Involvement in Patients with HER2-Positive Metastatic Breast Cancer: Focus on Elderly Patients.
Galve-Calvo, Elena; Alonso-Babarro, Alberto; Martínez-García, María; Pi-Figueras, María; Villalba, Gloria; Alonso, Saioa; Contreras, Jorge.
Afiliación
  • Galve-Calvo E; Medical Oncology Service, Hospital Universitario Basurto (OSI Bilbao-Basurto), Avda. Montevideo 18, 48013, Bilbao, Bisczy, Spain. ELENA.GALVECALVO@osakidetza.eus.
  • Alonso-Babarro A; Palliative Care Department, Hospital La Paz, Madrid, Spain.
  • Martínez-García M; Medical Oncology Department, Hospital Del Mar, Barcelona, Spain.
  • Pi-Figueras M; Geriatrics Service, Hospital del Mar, Barcelona, Spain.
  • Villalba G; Neurosurgery Service, Hospital del Mar, Barcelona, Spain.
  • Alonso S; Roche Farma S.A., Madrid, Spain.
  • Contreras J; Radiation Oncology Department, Hospital Carlos Haya, Málaga, Spain.
Adv Ther ; 40(8): 3304-3331, 2023 08.
Article en En | MEDLINE | ID: mdl-37291377
The tumor biology of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) promotes the development of central nervous system (CNS) metastases, with 25% of patients with HER2-positive BC developing CNS metastases. Furthermore, the incidence of HER2-positive BC brain metastases has increased in the last decades, likely because of the improved survival with targeted therapies and better detection methods. Brain metastases are detrimental to quality of life and survival and represent a challenging clinical problem, particularly in elderly women, who comprise a substantial proportion of patients diagnosed with BC and often have comorbidities or an age-related decline in organ function. Treatment options for patients with BC brain metastases include surgical resection, whole-brain radiation therapy, stereotactic radiosurgery, chemotherapy, and targeted agents. Ideally, local and systemic treatment decisions should be made by a multidisciplinary team, with input from several specialties, based on an individualized prognostic classification. In elderly patients with BC, additional age-associated conditions, such as geriatric syndromes or comorbidities, and the physiologic changes associated with aging, may impact their ability to tolerate cancer therapy and should be considered in the treatment decision-making process. This review describes the treatment options for elderly patients with HER2-positive BC and brain metastases, focusing on the importance of multidisciplinary management, the different points of view from the distinct disciplines, and the role of oncogeriatric and palliative care in this vulnerable patient group.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neoplasias de la Mama / Antineoplásicos Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Adv Ther Asunto de la revista: TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neoplasias de la Mama / Antineoplásicos Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Adv Ther Asunto de la revista: TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos