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Zeolitic imidazolate frameworks: From bactericidal properties to tissue regeneration.
Kermanian, Mehraneh; Nadri, Samad; Mohammadi, Parvin; Iravani, Siavash; Ahmadi, Nahid; Alinezhad, Vajihe; Shokrgozar, Mohammad-Ali; Haddad, Mahdi; Mostafavi, Ebrahim; Maleki, Aziz.
Afiliación
  • Kermanian M; Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
  • Nadri S; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Medicinal Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
  • Mohammadi P; Student Research Committee, School of Medicine(,) Zanjan University of Medical Sciences, Zanjan, Iran; Department of Medicinal Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Iravani S; Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Ahmadi N; Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
  • Alinezhad V; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
  • Shokrgozar MA; National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
  • Haddad M; Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
  • Mostafavi E; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ebimsv@stanford.edu.
  • Maleki A; Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran. Electronic address: Maleki@zums.ac.ir.
J Control Release ; 359: 326-346, 2023 07.
Article en En | MEDLINE | ID: mdl-37290724
Zeolitic imidazolate frameworks (ZIFs), as a very well-known subset of metal-organic frameworks (MOFs), have attracted considerable attention in biomedicine due to their unique structural features such as tunable pore size, high surface area, high thermal stability, biodegradability, and biocompatibility. Moreover, it is possible to load a wide variety of therapeutic agents, drugs, and biomolecules into ZIF structures during the fabrication process owing to the ZIFs' porous structure and concise synthesis methods under mild conditions. This review focuses on the most recent advances in the bioinspiration of ZIFs and ZIF-integrated nanocomposites in boosting antibacterial efficiencies and regenerative medicine capabilities. The first part summarizes the various synthesis routes and physicochemical properties of ZIFs, including size, morphology, surface, and pore size. The recent advancements in the antibacterial aspects of using ZIFs and ZIF-integrated nanocomposites as carriers for antibacterial agents and drug cargo are elaborated. Moreover, the antibacterial mechanisms based on the factors affecting the antibacterial properties of ZIFs such as oxidative stress, internal and external triggers, the effect of metal ions, and their associated combined therapies, are discussed. The recent trends of ZIFs and their composites in tissue regeneration, especially bone regeneration and wound healing, are also reviewed with in-depth perspectives. Finally, the biological safety aspects of ZIFs, the latest reports about their toxicity, and the future prospects of these materials in regenerative medicine have been discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zeolitas / Estructuras Metalorgánicas Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zeolitas / Estructuras Metalorgánicas Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos