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Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor.
Schürfeld, Robin; Sandner, Benjamin; Hoffmann, Annett; Klöting, Nora; Baratashvili, Ekaterine; Nowicki, Marcin; Paeschke, Sabine; Kosacka, Joanna; Kralisch, Susan; Bachmann, Anette; Frille, Armin; Dietel, Anja; Stolzenburg, Jens-Uwe; Blüher, Matthias; Zhang, Ming-Zhi; Harris, Raymond C; Isermann, Berend; Stumvoll, Michael; Tönjes, Anke; Ebert, Thomas.
Afiliación
  • Schürfeld R; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Sandner B; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Hoffmann A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Klöting N; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, Würzburg, Germany.
  • Baratashvili E; Helmholtz Institute for Metabolic, Obesity and Vascular Research of the Helmholtz Zentrum München at the University of Leipzig and University Hospital, Leipzig, Germany.
  • Nowicki M; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Paeschke S; Department of Cardiology, Angiology and Internal Intensive-Care Medicine, Klinikum St. Georg, Leipzig, Germany.
  • Kosacka J; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • Kralisch S; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • Bachmann A; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University of Leipzig Medical Center, Leipzig, Germany.
  • Frille A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Dietel A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Stolzenburg JU; Department of Respiratory Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
  • Blüher M; Department of Urology, University of Leipzig, Leipzig, Germany.
  • Zhang MZ; Department of Urology, University of Leipzig, Leipzig, Germany.
  • Harris RC; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
  • Isermann B; Helmholtz Institute for Metabolic, Obesity and Vascular Research of the Helmholtz Zentrum München at the University of Leipzig and University Hospital, Leipzig, Germany.
  • Stumvoll M; Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
  • Tönjes A; Department of Medicine, Nashville Veterans Affairs Hospital, Vanderbilt University School of Medicine, Nashville, TN, United States.
  • Ebert T; Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
Front Endocrinol (Lausanne) ; 14: 1152444, 2023.
Article en En | MEDLINE | ID: mdl-37288304
Objective: Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in conditions with impaired kidney function, so far. Design/methods: Serum ACBP concentrations were investigated by enzyme-linked immunosorbent assay i) in a cohort of 60 individuals with kidney failure (KF) on chronic haemodialysis and compared to 60 individuals with a preserved kidney function; and ii) in a human model of acute kidney dysfunction (AKD). In addition, mACBP mRNA expression was assessed in two CKD mouse models and in two distinct groups of non-CKD mice. Further, mRNA expression of mACBP was measured in vitro in isolated, differentiated mouse adipocytes - brown and white - after exposure to the uremic agent indoxyl sulfate. Results: Median [interquartile range] serum ACBP was almost 20-fold increased in KF (514.0 [339.3] µg/l) compared to subjects without KF (26.1 [39.1] µg/l) (p<0.001). eGFR was the most important, inverse predictor of circulating ACBP in multivariate analysis (standardized ß=-0.839; p<0.001). Furthermore, AKD increased ACBP concentrations almost 3-fold (p<0.001). Increased ACBP levels were not caused by augmented mACBP mRNA expression in different tissues of CKD mice in vivo or in indoxyl sulfate-treated adipocytes in vitro. Conclusions: Circulating ACBP inversely associates with renal function, most likely through renal retention of the cytokine. Future studies need to investigate ACBP physiology in malnutrition-related disease states, such as CKD, and to adjust for markers of renal function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidor de la Unión a Diazepam / Desnutrición Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidor de la Unión a Diazepam / Desnutrición Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza