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Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health.
Khan, Nadeem G; Tungekar, Bushra; Adiga, Divya; Chakrabarty, Sanjiban; Rai, Padmalatha S; Kabekkodu, Shama Prasada.
Afiliación
  • Khan NG; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Tungekar B; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Adiga D; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Chakrabarty S; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India; Center for DNA Repair and Genome Stability (CDRGS), Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Rai PS; Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Kabekkodu SP; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India; Center for DNA Repair and Genome Stability (CDRGS), Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Electronic address: shama.prasa
Biochim Biophys Acta Mol Cell Res ; 1870(7): 119505, 2023 10.
Article en En | MEDLINE | ID: mdl-37286138
Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Estrógenos Límite: Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Estrógenos Límite: Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos