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Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor.
Wei, Yinghui; Zhang, Meiling; Hu, Jing; Zhou, Yingsi; Xue, Mingxing; Yin, Jianhang; Liu, Yuanhua; Feng, Hu; Zhou, Ling; Li, Zhifang; Wang, Dongshuang; Zhang, Zhiguo; Zhou, Yin; Liu, Hongbin; Yao, Ning; Zuo, Erwei; Hu, Jiazhi; Du, Yanzhi; Li, Wen; Xu, Chunlong; Yang, Hui.
Afiliación
  • Wei Y; Center for Reproductive Medicine, International Peace Maternity and Child Health Hospital, Innovative Research Team of High-level Local Universities in Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Zhang M; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Hu J; Center for Reproductive Medicine, International Peace Maternity and Child Health Hospital, Innovative Research Team of High-level Local Universities in Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Zhou Y; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Xue M; Center for Reproductive Medicine, Anhui Provincial Maternal and Child Health Hospital, Hefei 230001, China.
  • Yin J; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Liu Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Feng H; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Zhou L; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Genome Editing Research Center, Peking University, Beijing 100871, China.
  • Li Z; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Wang D; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
  • Zhang Z; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
  • Zhou Y; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
  • Liu H; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Yao N; Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
  • Zuo E; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Hu J; Center for Reproductive Medicine, Shandong University, Jinan 250012, China.
  • Du Y; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Li W; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
  • Xu C; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Genome Editing Research Center, Peking University, Beijing 100871, China.
  • Yang H; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200127, China.
Protein Cell ; 14(6): 416-432, 2023 06 07.
Article en En | MEDLINE | ID: mdl-37285261
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citosina / Apolipoproteína E4 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Protein Cell Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citosina / Apolipoproteína E4 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Protein Cell Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania