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Therapeutic implications of cancer stem cells in prostate cancer.
Banerjee, Pinaki; Kapse, Prachi; Siddique, Shehnaz; Kundu, Moumita; Choudhari, Jasoda; Mohanty, Varshasnata; Malhotra, Diksha; Gosavi, Suresh W; Gacche, Rajesh N; Kundu, Gopal C.
Afiliación
  • Banerjee P; National Centre for Cell Science, Savitribai Phule Pune University Campus, Pune 411007, India.
  • Kapse P; School of Basic Medical Science, Savitribai Phule Pune University, Pune 411007, India.
  • Siddique S; School of Biotechnology, KIIT Deemed to be University, Bhubaneswar 751024, India.
  • Kundu M; School of Biotechnology, KIIT Deemed to be University, Bhubaneswar 751024, India.
  • Choudhari J; Department of Biotechnology, Savitribai Phule Pune University, Pune 411007, India.
  • Mohanty V; School of Biotechnology, KIIT Deemed to be University, Bhubaneswar 751024, India.
  • Malhotra D; School of Biotechnology, KIIT Deemed to be University, Bhubaneswar 751024, India.
  • Gosavi SW; School of Basic Medical Science, Savitribai Phule Pune University, Pune 411007, India.
  • Gacche RN; Department of Biotechnology, Savitribai Phule Pune University, Pune 411007, India.
  • Kundu GC; School of Biotechnology, KIIT Deemed to be University, Bhubaneswar 751024, India.
Cancer Biol Med ; 20(6)2023 06 05.
Article en En | MEDLINE | ID: mdl-37282627
Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata Límite: Humans / Male Idioma: En Revista: Cancer Biol Med Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata Límite: Humans / Male Idioma: En Revista: Cancer Biol Med Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: China