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Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation.
Lee, Kyungsene; Davis, Brandon; Wang, Xuelin; Mirg, Shubham; Wen, Connie; Abune, Lidya; Peterson, Benjamin E; Han, Li; Chen, Haoyang; Wang, Hongjun; Szczesny, Spencer E; Lei, Yuguo; Kothapalli, Sri-Rajasekhar; Wang, Yong.
Afiliación
  • Lee K; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Davis B; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Wang X; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Mirg S; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Wen C; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Abune L; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Peterson BE; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Han L; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Chen H; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Wang H; Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  • Szczesny SE; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Lei Y; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Kothapalli SR; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Wang Y; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
Angew Chem Int Ed Engl ; 62(31): e202306583, 2023 08 01.
Article en En | MEDLINE | ID: mdl-37277318
Cell encapsulation has been studied for various applications ranging from cell transplantation to biological production. However, current encapsulation technologies focus on cell protection rather than cell regulation that is essential to most if not all cell-based applications. Here we report a method for cell nanoencapsulation and regulation using an ultrathin biomimetic extracellular matrix as a cell nanocapsule to carry nanoparticles (CN2 ). This method allows high-capacity nanoparticle retention at the vicinity of cell surfaces. The encapsulated cells maintain high viability and normal metabolism. When gold nanoparticles (AuNPs) are used as a model to decorate the nanocapsule, light irradiation transiently increases the temperature, leading to the activation of the heat shock protein 70 (HSP70) promoter and the regulation of reporter gene expression. As the biomimetic nanocapsule can be decorated with any or multiple NPs, CN2 is a promising platform for advancing cell-based applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocápsulas / Nanopartículas / Nanopartículas del Metal Idioma: En Revista: Angew Chem Int Ed Engl Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocápsulas / Nanopartículas / Nanopartículas del Metal Idioma: En Revista: Angew Chem Int Ed Engl Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania