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Enantiomeric analysis of drugs in water samples by using liquid-liquid microextraction and nano-liquid chromatography.
Salido-Fortuna, Sandra; Bosco, Chiara Dal; Gentili, Alessandra; Castro-Puyana, María; Marina, María Luisa; D'Orazio, Giovanni; Fanali, Salvatore.
Afiliación
  • Salido-Fortuna S; Department of Chemistry, University of "La Sapienza", Rome, Italy.
  • Bosco CD; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
  • Gentili A; Department of Chemistry, University of "La Sapienza", Rome, Italy.
  • Castro-Puyana M; Department of Chemistry, University of "La Sapienza", Rome, Italy.
  • Marina ML; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
  • D'Orazio G; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
  • Fanali S; Istituto per i Sistemi Biologici (ISB), CNR - Consiglio Nazionale delle Ricerche, Montelibretti, Rome, Italy.
Electrophoresis ; 44(15-16): 1177-1186, 2023 08.
Article en En | MEDLINE | ID: mdl-37276371
The nano-LC technique is increasingly used for both fast studies on enantiomeric analysis and test beds of novel stationary phases due to the small volumes involved and the short conditioning and analysis times. In this study, the enantioseparation of 10 drugs from different families was carried out by nano-LC, utilizing silica with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) column. The effect on chiral separation caused by the addition of different salts to the mobile phase was evaluated. To simultaneously separate as many enantiomers as possible, the effect of buffer concentration in the mobile phase was studied, and, to increase the sensitivity, a liquid-liquid microextraction based on the use of isoamyl acetate as sustainable extraction solvent was applied to pre-concentrate four chiral drugs from tap and environmental waters, achieving satisfactory recoveries (>70%).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrocromatografía Capilar / Microextracción en Fase Líquida Límite: Humans Idioma: En Revista: Electrophoresis Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrocromatografía Capilar / Microextracción en Fase Líquida Límite: Humans Idioma: En Revista: Electrophoresis Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania