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Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial.
François, Bruno; Lambden, Simon; Fivez, Tom; Gibot, Sebastien; Derive, Marc; Grouin, Jean-Marie; Salcedo-Magguilli, Margarita; Lemarié, Jérémie; De Schryver, Nicolas; Jalkanen, Ville; Hicheur, Tarik; Garaud, Jean-Jacques; Cuvier, Valérie; Ferrer, Ricard; Bestle, Morten; Pettilä, Ville; Mira, Jean-Paul; Bouisse, Camille; Mercier, Emmanuelle; Vermassen, Joris; Huberlant, Vincent; Vinatier, Isabelle; Anguel, Nadia; Levy, Mitchell; Laterre, Pierre-François.
Afiliación
  • François B; Medical-Surgical ICU Department and Inserm CIC1435 & UMR1092, CRICS-TRIGGERSEP Network, CHU Limoges, Limoges, France. Electronic address: bruno.francois@chu-limoges.fr.
  • Lambden S; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; Inotrem, Paris, France.
  • Fivez T; Ziekenhuis Oost-Limburg, Genk, Belgium.
  • Gibot S; Intensive Care Unit, Centre Hospitalier Regional Universitaire, Nancy, France.
  • Derive M; Inotrem, Paris, France.
  • Grouin JM; Statistics Department, Université de Rouen, Mont Saint-Aignan, France.
  • Salcedo-Magguilli M; Inotrem, Paris, France.
  • Lemarié J; CHU de Nantes, Nantes, France.
  • De Schryver N; Clinique Saint Pierre, Ottignies, Belgium.
  • Jalkanen V; Tampere University Hospital, Intensive Care Unit, Tampere, Finland.
  • Hicheur T; Inotrem, Paris, France.
  • Garaud JJ; Inotrem, Paris, France.
  • Cuvier V; Inotrem, Paris, France.
  • Ferrer R; Intensive Care Department, Hospital Universitari Vall d'Hebron, SODIR Research Group, Vall d'Hebron Institut de Recerca, Spain; Paseig de la Vall d'Hebron, Barcelona, Spain.
  • Bestle M; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-North Zealand, Denmark; Department of Clinical Medicine, University of Copenhagen, Hilleroed, Denmark.
  • Pettilä V; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Mira JP; Groupe Hospitalier Cochin St Vincent de Paul La Roche Guyon, Paris, France.
  • Bouisse C; Centre Hospitalier de Bourg-en-Bresse, Bourg-en-Bresse, France.
  • Mercier E; Hôpital Bretonneau, Tours, France.
  • Vermassen J; Universitair Ziekenhuis Gent, Gent, Belgium.
  • Huberlant V; Centre Hospitalier Jolimont-Lobbes, Haine-Saint-Paul, Belgium.
  • Vinatier I; Centre Hospitalier Départemental de Vendée, La Roche-sur-Yon, France.
  • Anguel N; Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
  • Levy M; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
  • Laterre PF; Department of Critical Care Medicine, CHR Mons-Hainaut, Mons, Belgium.
Lancet Respir Med ; 11(10): 894-904, 2023 10.
Article en En | MEDLINE | ID: mdl-37269870
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Respir Med Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Respir Med Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido