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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis.
Kim, Su-Man; Park, Shinhye; Hwang, Seung-Ho; Lee, Eun-Young; Kim, Jong-Hwan; Lee, Ga Seul; Lee, Giljae; Chang, Dong-Ho; Lee, Jae-Geun; Hwang, Jungwon; Lee, Youngjin; Kyung, Minsoo; Kim, Eun-Kyoung; Kim, Jae-Hoon; Kim, Tae-Hwan; Moon, Jeong Hee; Kim, Byoung-Chan; Ko, GwangPyo; Kim, Seon-Young; Ryu, Ji-Hwan; Lee, Jeong-Soo; Lee, Chul-Ho; Kim, Jeong-Yoon; Kim, Sunghoon; Lee, Won-Jae; Kim, Myung Hee.
Afiliación
  • Kim SM; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea; Department of Biology Education, Chonnam National University, Gwangju 61186, Korea.
  • Park S; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea; Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Korea.
  • Hwang SH; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Lee EY; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Kim JH; Korean Bioinformation Center, KRIBB, Daejeon 34141, Korea.
  • Lee GS; Core Research Facility & Analysis Center, KRIBB, Daejeon 34141, Korea; College of Pharmacy, Chungbuk National University, Cheongju 28160, Chungbuk, Korea.
  • Lee G; Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
  • Chang DH; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Lee JG; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Hwang J; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Lee Y; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
  • Kyung M; National Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
  • Kim EK; National Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
  • Kim JH; Laboratory Animal Resource Center, KRIBB, Daejeon 34141, Korea.
  • Kim TH; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea; College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.
  • Moon JH; Core Research Facility & Analysis Center, KRIBB, Daejeon 34141, Korea.
  • Kim BC; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea; HealthBiome, Inc., Bioventure Center, Daejeon 34141, Korea.
  • Ko G; Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea; Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul 08826, Korea; KoBioLabs, Inc., Seoul 08826, Korea; Bio-MA
  • Kim SY; Korean Bioinformation Center, KRIBB, Daejeon 34141, Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea.
  • Ryu JH; Severance Biomedical Science Institute and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
  • Lee JS; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea.
  • Lee CH; Laboratory Animal Resource Center, KRIBB, Daejeon 34141, Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea.
  • Kim JY; Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Korea.
  • Kim S; Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy and College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon 21983, Republic of Korea.
  • Lee WJ; National Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
  • Kim MH; Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea. Electronic address: mhk8n@kribb.re.kr.
Cell Host Microbe ; 31(6): 1021-1037.e10, 2023 06 14.
Article en En | MEDLINE | ID: mdl-37269833
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, the molecular mechanisms of which are just being uncovered. All kingdoms of life produce aminoacyl-tRNA synthetases (ARSs). Thus far, the non-translational roles of ARSs have largely been reported in eukaryotes. Here, we report that the threonyl-tRNA synthetase (AmTARS) of the gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor and modulate immune homeostasis. Secreted AmTARS triggers M2 macrophage polarization and orchestrates the production of anti-inflammatory IL-10 via its unique, evolutionary-acquired regions, which mediates specific interactions with TLR2. This interaction activates the MAPK and PI3K/AKT signaling pathways, which converge on CREB, leading to an efficient production of IL-10 and suppression of the central inflammatory mediator NF-κB. AmTARS restores IL-10-positive macrophages, increases IL-10 levels in the serum, and attenuates the pathological effects in colitis mice. Thus, commensal tRNA synthetases can act as intrinsic mediators that maintain homeostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Treonina-ARNt Ligasa Límite: Animals Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Treonina-ARNt Ligasa Límite: Animals Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos