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Tocilizumab for antibody-mediated rejection treatment in lung transplantation.
January, Spenser E; Fester, Keith A; Halverson, Laura P; Witt, Chad A; Byers, Derek E; Vazquez-Guillamet, Rodrigo; Alexander-Brett, Jennifer; Tague, Laneshia K; Kreisel, Daniel; Gelman, Andrew; Puri, Varun; Bahena, Ruben Nava; Takahashi, Tsuyoshi; Hachem, Ramsey R; Kulkarni, Hrishikesh S.
Afiliación
  • January SE; Department of Pharmacy, Barnes-Jewish Hospital , Saint Louis, Missouri. Electronic address: spenser.january@bjc.org.
  • Fester KA; Department of Pharmacy, Barnes-Jewish Hospital , Saint Louis, Missouri.
  • Halverson LP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Witt CA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Byers DE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Vazquez-Guillamet R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Alexander-Brett J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Tague LK; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Kreisel D; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.
  • Gelman A; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.
  • Puri V; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.
  • Bahena RN; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.
  • Takahashi T; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.
  • Hachem RR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
  • Kulkarni HS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
J Heart Lung Transplant ; 42(10): 1353-1357, 2023 10.
Article en En | MEDLINE | ID: mdl-37268051
Tocilizumab (TCZ), an IL-6 inhibitor, has shown promise in the treatment of donor-specific antibodies (DSA) and chronic antibody-mediated rejection (AMR) in renal transplant recipients. However, its use in lung transplantation has not been described. This retrospective case-control study compared AMR treatments containing TCZ in 9 bilateral lung transplant recipients to 18 patients treated for AMR without TCZ. Treatment with TCZ resulted in more clearance of DSA, lower recurrence of DSA, lower incidence of new DSA, and lower rates of graft failure when compared to those treated for AMR without TCZ. The incidence of infusion reactions, elevation in transaminases, and infections were similar between the 2 groups. These data support a role for TCZ in pulmonary AMR and establish preliminary evidence to design a randomized controlled trial of IL-6 inhibition for the management of AMR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Trasplante de Pulmón Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Trasplante de Pulmón Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos