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Urinary phenylacetylglutamine as a possible biomarker for central nervous system disorders in forensic autopsy cases.
Ikematsu, Natsuki; Hara, Kenji; Waters, Brian; Matsusue, Aya; Takayama, Mio; Kashiwagi, Masayuki; Kubo, Shin-Ichi.
Afiliación
  • Ikematsu N; Department of Legal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
  • Hara K; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan.
  • Waters B; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan.
  • Matsusue A; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan.
  • Takayama M; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan.
  • Kashiwagi M; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan.
  • Kubo SI; Department of Forensic Medicine, Fukuoka University, Fukuoka, Japan. Electronic address: kuboshin@fukuoka-u.ac.jp.
Leg Med (Tokyo) ; 64: 102274, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37267737
Phenylacetylglutamine (PAG) is a metabolite that is excreted in human urine. Phenylalanine is metabolized to phenylacetic acid, which is then amide-bonded to glutamine to form PAG. We are currently studying PAG as a urinary biomarker in forensic autopsy cases. MATERIALS AND METHODS: Urine samples were collected from 188 forensic autopsy cases and the urinary PAG concentration was analyzed quantitatively using GC-MS. Urinary creatinine (Cr) concentration was also analyzed by GC-MS. For statistical analysis, the JMP Pro 15.0.0 software program was used. The relationship between urine PAG/Cr (the ratio of each concentration), sex, age, postmortem interval (PMI), survival duration, and cause of death was statistically analyzed. RESULTS AND DISCUSSION: The median (range) of PAG/Cr was 0.12 (0.002-3.26). The PAG/Cr ratio showed no significant relationship to sex or survival duration. Regarding the cause of death, traumatic brain injuries had a significantly higher ratio than intoxication (p=0.023). Cerebrovascular disease, such as cerebral hemorrhage and subarachnoid hemorrhage, did not differ significantly from any cause of death group. However, when traumatic brain injuries and cerebrovascular accidents are combined as one cause of death group, the PAG/Cr value of CNS damages was significantly higher than that of intoxication (p=0.062). CONCLUSION: Urinary PAG/Cr might be a biomarker not only for traumatic brain injuries but also for antemortem CNS damages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Traumáticas del Encéfalo / Glutamina Límite: Humans Idioma: En Revista: Leg Med (Tokyo) Asunto de la revista: JURISPRUDENCIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Traumáticas del Encéfalo / Glutamina Límite: Humans Idioma: En Revista: Leg Med (Tokyo) Asunto de la revista: JURISPRUDENCIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda