Toward computational neuroconstructivism: a framework for developmental systems neuroscience.
Trends Cogn Sci
; 27(8): 726-744, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37263856
Brain development is underpinned by complex interactions between neural assemblies, driving structural and functional change. This neuroconstructivism (the notion that neural functions are shaped by these interactions) is core to some developmental theories. However, due to their complexity, understanding underlying developmental mechanisms is challenging. Elsewhere in neurobiology, a computational revolution has shown that mathematical models of hidden biological mechanisms can bridge observations with theory building. Can we build a similar computational framework yielding mechanistic insights for brain development? Here, we outline the conceptual and technical challenges of addressing this theory gap, and demonstrate that there is great potential in specifying brain development as mathematically defined processes operating within physical constraints. We provide examples, alongside broader ingredients needed, as the field explores computational explanations of system-wide development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Neurociencias
Límite:
Humans
Idioma:
En
Revista:
Trends Cogn Sci
Asunto de la revista:
PSICOLOGIA
Año:
2023
Tipo del documento:
Article
Pais de publicación:
Reino Unido