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Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents.
Wolters, Maike; Marron, Manuela; Foraita, Ronja; Hadjigeorgiou, Charalampos; De Henauw, Stefaan; Eiben, Gabriele; Lauria, Fabio; Iglesia, Iris; Moreno, Luis A; Molnár, Dénes; Veidebaum, Toomas; Ahrens, Wolfgang; Nagrani, Rajini.
Afiliación
  • Wolters M; Leibniz Institute for Prevention Research and Epidemiology - BIPS, D-28359 Bremen, Germany.
  • Marron M; Leibniz Institute for Prevention Research and Epidemiology - BIPS, D-28359 Bremen, Germany.
  • Foraita R; Leibniz Institute for Prevention Research and Epidemiology - BIPS, D-28359 Bremen, Germany.
  • Hadjigeorgiou C; Research and Education Institute of Child Health, 2027 Strovolos, Cyprus.
  • De Henauw S; Department of Public Health and Primary Care, Ghent University, 9000 Ghent, Belgium.
  • Eiben G; Department of Public Health and Community Medicine, University of Gothenburg, 40530 Gothenburg, Sweden.
  • Lauria F; Department of Public Health, School of Health Sciences, University of Skövde, 541 28 Skövde, Sweden.
  • Iglesia I; Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.
  • Moreno LA; GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain.
  • Molnár D; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0012, Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Veidebaum T; GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain.
  • Ahrens W; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Nagrani R; Department of Paediatrics, Medical School, University of Pécs, 7623 Pécs, Hungary.
J Clin Endocrinol Metab ; 108(12): e1731-e1742, 2023 Nov 17.
Article en En | MEDLINE | ID: mdl-37261399
CONTEXT: Vitamin D status has previously been associated with cardiometabolic risk markers in children and adolescents. In particular, it has been suggested that children with obesity are more prone to vitamin D deficiency and unfavorable metabolic outcomes compared with healthy-weight children. OBJECTIVE: To conduct a longitudinal study assessing this association in children and stratify by body mass index (BMI) category. METHODS: Children from the pan-European IDEFICS/I.Family cohort with at least one measurement of serum 25-hydroxyvitamin D [25(OH)D] at cohort entry or follow-up (n = 2171) were included in this study. Linear mixed-effect models were used to assess the association between serum 25(OH)D as an independent variable and z-scores of cardiometabolic risk markers (waist circumference, systolic [SBP] and diastolic blood pressure [DBP], high- [HDL] and low-density lipoprotein, non-HDL, triglycerides [TRG], apolipoprotein A1 [ApoA1] and ApoB, fasting glucose [FG], homeostatic model assessment for insulin resistance [HOMA-IR], and metabolic syndrome score) as dependent variables. RESULTS: After adjustment for age, sex, study region, smoking and alcohol status, sports club membership, screen time, BMI, parental education, and month of blood collection, 25(OH)D levels were inversely associated with SBP, DBP, FG, HOMA-IR, and TRG. The HOMA-IR z-score decreased by 0.07 units per 5 ng/mL increase in 25(OH)D. The 25(OH)D level was consistently associated with HOMA-IR irrespective of sex or BMI category. CONCLUSION: Low serum 25(OH)D concentrations are associated with unfavorable levels of cardiometabolic markers in children and adolescents. Interventions to improve vitamin D levels in children with a poor status early in life may help to reduce cardiometabolic risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Resistencia a la Insulina / Enfermedades Cardiovasculares / Síndrome Metabólico Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Resistencia a la Insulina / Enfermedades Cardiovasculares / Síndrome Metabólico Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos